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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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TGFB1
transforming growth factor beta 1

Gene

Official Symbol	TGFB1
Official Full Name	transforming growth factor beta 1
CGNC ID	65904
also known as	TGF-beta4, TGFB4, transforming growth factor beta-1 proprotein\|transforming growth factor beta-1\|TGF-beta-1\|tissue growth factor-beta4\|transforming growth factor beta 4
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	AF395834
Polypeptide	AAL05481
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.929

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human
Mouse
Xenopus
Zebrafish

Gene Ontology

Molecular Function	growth factor activity, transforming growth factor beta receptor binding
Biological Process	cell growth, positive regulation of cell division, more...
Cellular Component	extracellular space

Links to other databases

Entrez Gene	100873157
Ensembl Gene
KEGG

Entry 1

GEISHA Id	ChEST673k20	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GCGCGCTCTCCACGTGCCAACGGCTGGACCTGGAGGCGGCCAAAAAGAAACGCATCGAGGCGGTGCGGGGTCAAATCCT CAGCAAACTGCGTCTGACCGCGCCCCCCCCCGCCTCCGAGACCCCCCCCCGCCCCCTGCCCGACGACGTCCGGGCTCTG TACAACAGCACCCAGGAGCTGCTGAAGCAGCGCGCCCGACTGCGGCCCCCCCCGGATGGACCCGATGAGTATTGGGCCA AAGAGCTGCGGCGGATCCCCATGGAGACCACCTGGGACGGCGCCATGGAGCATTGGCAGCCGCAGAGCCACAGCATCTT CTTCGTGTTCAACGTGTCCCGTGCGCGCAGAGGTGGGCGGCCGACGCTGCTGCACCGCGCCGAGCTGAGGATGCTGCGG CAAAAGGCGGCCGCCGACAGCGCCGGCACCGAACAGCGGCTGGAGCTGTACCAGGGTTACGGCAATGCCTCGTGGCGGT ACCTGCATGGCCGCTCCGTGCGCGCCACGGCCGACGATGAGTGGCTCTCCTTCGACGTCACCGACGCCGTCCATCAGTG GCTGAGCGGCAGCGAGCTCCTGGGGGTCTTCAAGCTGAGCGTGCACTGTCCCTGTGAGATGGGCCCCGGCCACGCCGAA GAGATGCGCATCTCCATCGAAGGCTTCGAGCAGCAGCGCGGGGACATGCAGAGCATTGCCAAGAAGCACCGCCGCGTGC CGTACGTCCTGGCCATGGCGCTGCCGGCCGAGCGCGCCAATGAGCTGCACAGCGCCCGGCGGCGGCGCGACCTCGACAC CGACTACTGCTTCGGCCCCGGGACGGATGAGAAGAACTGCTGCGTGCGGCCGCTCTACATCGACTTCCGCAAGGATCTG CAGTGGAAGTGGATCCACGAACCCAAAGGTTATATGGCCAACTTCTGCATGGGGCCGTGCCCGTACATCTGGAGCGCCG ACACGCAGTACACCAAGGTGCTGGCGCTGTACAACCAACACAACCCGGGGGCTTCGGCCGCTCCGTGCTGCGTCCCGCA GACCCTCGACCCCCTCCCCATCATTTACTACGTGGGCCGGAATGTGCGCGTGGAGCAGCTCTCCAATATGGTGGTCCGT GCCTGCAAGTGCAGCTGACCCCCCCTCGGGACCCCCACCACCCCTTCAAAACACCGGACCTCCCCCCCCCCTCCCCACC AACCCCCCCCCCACAACGAGAGGATTTATTTAAGTTTTAGATGGTTCCCTTTTTGGGGGTTTTTTGGACAG

Stage

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Location (click to highlight)

Comments (click to highlight)

1-3

stage 3

Area Pellucida
Primitive Streak

7-12

stage 7

stage 8

stage 9

stage 10

stage 11

stage 12

Area Opaca
Blood Islands
Blood Vessels
Endocardium
Extraembryonic Mesoderm
Head Mesenchyme
Heart
Heart Tube
Lateral Plate Mesoderm
Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak
Somites
Widespread Expression

13-18

stage 14

stage 15

stage 16

stage 17

Area Opaca
Area Pellucida
Blood Islands
Blood Vessels
Endocardium
Head Mesenchyme
Heart
Myotome
Neural Plate/Tube
Paraxial Mesoderm
Somites
Widespread Expression

Sections Completed

19-24

stage 20

stage 21

Widespread Expression

stage 25

Widespread Expression

Entry 2

GEISHA Id	TGFB.Halper.2005	Data Source	Publication
Complete cDNA Template Probe	show GGGGGAACGGAGCGGTACCGGCGGCGGAGCGGCACCGGGGGGGCAGCAGCCGGGGGAATCCCGCAGCCGCGCCTACGGG GGATCCCGGCCCCTTTGCGGGGGGGGAGGGGTCCCGGTGCCCCATCGGAGTTATTTGGGGGGGGGTCCCTCCGCCCCCC CCCATGGATCCGTCGCCGCTGCTGGCGCTGCTGCTGCTGCTGCTGGGGGCCGCCCGCGCGCTCTCCACGTGCCAACGGC TGGACCTGGAGGCGGCCAAAAAGAAACGCATCGAGGCGGTGCGGGGTCAAATCCTCAGCAAACTGCGTCTGACCGCGCC CCCCCCCGCCTCCGAGACCCCCCCCCGCCCCCTGCCCGACGACGTCCGGGCTCTGTACAACAGCACCCAGGAGCTGCTG AAGCAGCGCGCCCGACTGCGGCCCCCCCCGGATGGACCCGATGAGTATTGGGCCAAAGAGCTGCGGCGGATCCCCATGG AGACCACCTGGGACGGCCCCATGGAGCATTGGCAGCCGCAGAGCCACAGCATCTTCTTCGTGTTCAACGTGTCCCGCGT GCGCGCAGAGGTGGGCGGCCGAGCGCTGCTGCACCGCGCCGAGCTGAGGATGCTGCGGCAAAAGGCGGCCGCCGACAGC GCCGGCACCGAACAGCGGCTGGAGCTGTACCAGGGTTACGGCAATGCCTCGTGGCGGTACCTGCATGGCCGCTCCGTGC GCGCCACGGCCGACGATGAGTGGCTCTCCTTCGACGTCACCGACGCCGTCCATCAGTGGCTGAGCGGCAGCGAGCTCCT GGGGGTCTTCAAGCTGAGCGTGCACTGTCCCTGTGAGATGGGCCCCGGCCACGCCGACGAGATGCGCATCTCCATCGAA GGCTTCGAGCAGCAGCGCGGGGACATGCAGAGCATTGCCAAGAAGCACCGCCGCGTGCCGTACGTCCTGGCCATGGCGC TGCCGGCCGAGCGCGCCAATGAGCTGCACAGCGCCCGGCGGCGGCGCGACCTCGACACCGACTACTGCTTCGGCCCCGG GACGGATGAGAAGAACTGCTGCGTGCGGCCGCTCTACATCGACTTCCGCAAGGATCTGCAGTGGAAGTGGATCCACGAA CCCAAAGGTTATATGGCCAACTTCTGCATGGGGCCGTGCCCGTACATCTGGAGCGCCGACACGCAGTACACCAAGGTGC TGGCGCTGTACAACCAACACAACCCGGGGGCTTCGGCCGCTCCGTGCTGCGTCCCGCAGACCCTCGACCCCCTCCCCAT CATTTACTACGTGGGCCGGAATGTGCGCGTGGAGCAGCTCTCCAATATGGTGGTCCGTGCCTGCAAGTGCAGCTGACCC CCCCTCGGGACCCCCACCACCCCTTCAAAACACCGGACCTCCCCCCCCCCTCCCCACCAACCCCCCCCCCACAACGAGA GGATTTATTTAAGTTTTAGATGGTTCCCTTTTTGGGGGTTTTTTGGACAG
Citation	Halper J, Griffin A, Hu W, Jung C, Zhang J, Pan H, Kisaalita WS, Foutz TL, Frazier KS. In vitro culture decreases the expression of TGF(beta), Hsp47 and type I procollagen and increases the expression of CTGF in avian tendon explants. J Musculoskelet Neuronal Interact. 2005 Mar;5(1):53-63.
Copyright	Copyright 2005 International Society of Musculoskeletal and Neuronal Interactions
Comments	Authors said: We constructed a 512 bp long RNA probe complementa- ry to a segment of 2745 bp long human TGF1 mRNA between 1486 and 1998 bases. This probe has 92% homolo- gy to the corresponding chicken TGF1 cDNA sequence and 73% homology to chicken TGF3 cDNA sequence24. We used the following set of primers: forward primer: 5'-ATTTAGGTGACACTATATGAGGGCTTTCGCCTTAG-3' reverse primer: 5'-TAATACGACTCACTATAGGGCGCACGCACGAT CATGTTGGAC-3'. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # JQ423909.1).