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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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NBL1
neuroblastoma 1, DAN family BMP antagonist

Gene

Official Symbol	NBL1
Official Full Name	neuroblastoma 1, DAN family BMP antagonist
CGNC ID	2967
also known as	MINOS1-NBL1, neuroblastoma suppressor of tumorigenicity 1\|MINOS1-NBL1 readthrough\|cDAN\|cysteine knot secreted protein DAN\|neuroblastoma, suppression of tumorigenicity 1
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204149
Polypeptide	NP_989480
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.156

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4681	ENSG00000158747		MIM:600613
Mouse	17965	ENSMUSG00000041120	All phenotypic alleles (5):Targeted, knock-out(2) Targeted, other(3)	MGI:104591
Xenopus	448558, 373697			479180
Zebrafish	404629		ZDB-GENE-040426-2357	ZFIN:ZDB-GENE-040426-2357

Gene Ontology

Molecular Function	BMP binding, morphogen activity
Biological Process	determination of dorsal identity, negative regulation of monocyte chemotaxis, more...
Cellular Component	extracellular region

Links to other databases

Entrez Gene	373952
Ensembl Gene	ENSGALG00000004043
KEGG	gga:373952

Entry 1

GEISHA Id	DAN.Katsu.2012	Data Source	Publication
Complete cDNA Template Probe	show AATTCGCGGCCGCGAGGCAGCGAGGGAAGGAGGGAGGGAAGAAGGGAGGCGGCAGCTCCCGCCCGCCCCGCGCCTCCGG GGGCCGCGGCGCCGAGGATGCGGCAGCCGCCGGGCACCGCGGGGCTGTAACCGCCCGCAGCCGTCGCCCGCGGCCCCGG AGCCCATGGGATGTGCCCGCCGTCTCCTGGGTGTTGCAGATTTTCGGCAGAGCTGGCCATGATGTTATGGNTTGTGGTC GGAGCCCTCTTCCCAGCGCTGCTCCTGGCTGCGCCGCCTCCCATAAACAAACTCGCCCTTTTCCCGGATAAGAGTGCTT GGTGCGAGGCAAAGAACATCACCCAGATCGTGGGGCACAGCGGCTGCGAGTCCAAGTCCATCCAGAACAGGGCCTGCCT GGGGCAGTGTTTCAGCTACAGTGTCCCCAACACCTTCCCTCAGTCCACAGAGTCCCTGGTTCACTGCGACTCCTGCATG CCAGCCCAGTCCATGTGGGAAATCGTGACACTGGACTGCCCAGGCAACGACGAGATCCCCAGGGTTGACAAGCTGGTGG AGAAGATACTTCACTGCAGCTGCCAGGCTTGTGGCAAGGAGCCAAGCCACGAGGGAGCCCTGTTCAATGTCTACTTGAA CGCAGAGGAGAACATGCCCGCAGAGGGCCCCGGCCCCCACCACTATGCCCACCACCAACAGGAGGTAGAAGAGCCCCCT GCTTCCAGCCACCACCACCACGAGGAGGAGGGCGACGAGTGACCCGGCCCTCGTGGACTGTCCTTGCAGCACGGGCAGG GAGTGTGTGCGAGGGAGAGGGCCAGGGCCTGGGGAGGGAGGGGGGTGGTGGAGGCTTTCCTGTCTAATAGCTACCCTCA CGCTTTGCTCTCCACAACACCCCGGGGCTGGAGGAGTGTTTTGAGGCACGAGCAGGACGTGGGGCTGGAGCTGCGGGGC CAAAGGAGGGCTGGGGGTTTCTGTTGCAAAACTACTTGCACATCATAGTAATAATATATTGAGAGAAGTGGGAACGTGG GCAGAGGGGGCTCTGGCAGAGAGCAGGAGCCAAGCTGGGCTCCCCAAGGGCTGTCTGCAGGATCCTTAGTCTGCTGTGG AGTCCTTGATGAGCCCTCTGGGATTTTCTTTTGTATGTGGCTCTTGCCTGGCCTGGAGAAAGAAGGGACGCAGCTTCCC TGCAGCCACGCAAGAGATGCACATCTCTTCTGCGGCGTATGGGATGGGGGTCTCCCTTCTTCCTCACACTTCCCCTGCC TGCCCAGGGGTGCCTGAGCTCAGCATGGGTGCTGTTCCTCCTGGCACTCACTGGGTCTTACTTCAACCCCCGTGCGTCG TGTTAGGTAGCTCATAGGGAGTATTTTGCCCTGGCTGTGCCTCCGGGGCTGTGTGTGAGGTTGCTGGGAGCCACGGTGG TCAGAGCCCTTTCCCTGCTGGTCCTCAGGGCCACCACATAGCTTGCAAGGGCGAGGGAGCTGCACTGTGTCATGGGCAC TGGGGTTTCACGTTTCACAGCCCATGGTGGGGTGGCGTGGGTAGGAGCTGGCCCCTCTCCCCTCCTTCCCTGCTGCACT TTAATTGTGGTGGAGGGAGAAGGGAGACAAGTCCTGGGATGCTGATGGACCTCTGTAGGGGATTGCTCTGGACCCCACT GCAGATGCAGGGCTGGGCTCAGGGTGGGGGCCCCTCCTGCTACCCCTCTCTCTGTTGTATAAAGCTAATTTCTTTGGCA CTGTCCTGACAAAAGCTTCCAGAGCTTGTAACCGATGCCTCCCTCTCCTTTTTACAAGTTTTGGTTTGTGTTTTTTGTT GGTTTTTGTTTTTGTTTTCTTAAATAAATTAGTTCTGACTTCCGCGGCCGCGAATTC
Citation	Katsu K, Tokumori D, Tatsumi N, Suzuki A, Yokouchi Y. BMP inhibition by DAN in Hensen's node is a critical step for the establishment of left-right asymmetry in the chick embryo. Dev Biol. 2012 Mar 1;363(1):15-26.
Copyright	Copyright © 2012. Published by Elsevier Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # AB044337.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 5

stage 6

Early Mesoderm
Head Process
Hensen's Node

HH5+ embryo
control embryo

7-8

stage 7

stage 8

Early Mesoderm
Head Process
Hensen's Node
Neural Plate/Tube
Somites

Entry 2

GEISHA Id	Dan.Ogita.2001	Data Source	Publication
Complete cDNA Template Probe	show AATTCGCGGCCGCGAGGCAGCGAGGGAAGGAGGGAGGGAAGAAGGGAGGCGGCAGCTCCCGCCCGCCCCGCGCCTCCGG GGGCCGCGGCGCCGAGGATGCGGCAGCCGCCGGGCACCGCGGGGCTGTAACCGCCCGCAGCCGTCGCCCGCGGCCCCGG AGCCCATGGGATGTGCCCGCCGTCTCCTGGGTGTTGCAGATTTTCGGCAGAGCTGGCCATGATGTTATGGNTTGTGGTC GGAGCCCTCTTCCCAGCGCTGCTCCTGGCTGCGCCGCCTCCCATAAACAAACTCGCCCTTTTCCCGGATAAGAGTGCTT GGTGCGAGGCAAAGAACATCACCCAGATCGTGGGGCACAGCGGCTGCGAGTCCAAGTCCATCCAGAACAGGGCCTGCCT GGGGCAGTGTTTCAGCTACAGTGTCCCCAACACCTTCCCTCAGTCCACAGAGTCCCTGGTTCACTGCGACTCCTGCATG CCAGCCCAGTCCATGTGGGAAATCGTGACACTGGACTGCCCAGGCAACGACGAGATCCCCAGGGTTGACAAGCTGGTGG AGAAGATACTTCACTGCAGCTGCCAGGCTTGTGGCAAGGAGCCAAGCCACGAGGGAGCCCTGTTCAATGTCTACTTGAA CGCAGAGGAGAACATGCCCGCAGAGGGCCCCGGCCCCCACCACTATGCCCACCACCAACAGGAGGTAGAAGAGCCCCCT GCTTCCAGCCACCACCACCACGAGGAGGAGGGCGACGAGTGACCCGGCCCTCGTGGACTGTCCTTGCAGCACGGGCAGG GAGTGTGTGCGAGGGAGAGGGCCAGGGCCTGGGGAGGGAGGGGGGTGGTGGAGGCTTTCCTGTCTAATAGCTACCCTCA CGCTTTGCTCTCCACAACACCCCGGGGCTGGAGGAGTGTTTTGAGGCACGAGCAGGACGTGGGGCTGGAGCTGCGGGGC CAAAGGAGGGCTGGGGGTTTCTGTTGCAAAACTACTTGCACATCATAGTAATAATATATTGAGAGAAGTGGGAACGTGG GCAGAGGGGGCTCTGGCAGAGAGCAGGAGCCAAGCTGGGCTCCCCAAGGGCTGTCTGCAGGATCCTTAGTCTGCTGTGG AGTCCTTGATGAGCCCTCTGGGATTTTCTTTTGTATGTGGCTCTTGCCTGGCCTGGAGAAAGAAGGGACGCAGCTTCCC TGCAGCCACGCAAGAGATGCACATCTCTTCTGCGGCGTATGGGATGGGGGTCTCCCTTCTTCCTCACACTTCCCCTGCC TGCCCAGGGGTGCCTGAGCTCAGCATGGGTGCTGTTCCTCCTGGCACTCACTGGGTCTTACTTCAACCCCCGTGCGTCG TGTTAGGTAGCTCATAGGGAGTATTTTGCCCTGGCTGTGCCTCCGGGGCTGTGTGTGAGGTTGCTGGGAGCCACGGTGG TCAGAGCCCTTTCCCTGCTGGTCCTCAGGGCCACCACATAGCTTGCAAGGGCGAGGGAGCTGCACTGTGTCATGGGCAC TGGGGTTTCACGTTTCACAGCCCATGGTGGGGTGGCGTGGGTAGGAGCTGGCCCCTCTCCCCTCCTTCCCTGCTGCACT TTAATTGTGGTGGAGGGAGAAGGGAGACAAGTCCTGGGATGCTGATGGACCTCTGTAGGGGATTGCTCTGGACCCCACT GCAGATGCAGGGCTGGGCTCAGGGTGGGGGCCCCTCCTGCTACCCCTCTCTCTGTTGTATAAAGCTAATTTCTTTGGCA CTGTCCTGACAAAAGCTTCCAGAGCTTGTAACCGATGCCTCCCTCTCCTTTTTACAAGTTTTGGTTTGTGTTTTTTGTT GGTTTTTGTTTTTGTTTTCTTAAATAAATTAGTTCTGACTTCCGCGGCCGCGAATTC
Citation	Ogita J, Isogai E, Sudo H, Sakiyama S, Nakagawara A, Koseki H. Expression of the Dan gene during chicken embryonic development. Mech Dev. 2001 Dec;109(2):363-5.
Copyright	Copyright © 2001 Elsevier Science Ireland Ltd.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Ogita et al. 2001. DAN is also known as NBL1 in NCBI.

Stage

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Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Epiblast
Hensen's Node

7-12

stage 8

stage 9

Ear/Otic Placode
Head Mesenchyme
Neural Plate/Tube
Notochord
Somites

13-18

stage 13

Dermomyotome
Endoderm
Eye
Forebrain
Head Mesenchyme
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Surface Ectoderm

19-24

stage 19

stage 24

Aorta
Cranial PNS
Ear/Otic Placode
Esophagus
Eye
Foregut
Gut
Head Mesenchyme
Leg AER
Leg Mesenchyme
Limb Buds
Mesonephros
Myotome
Nephric Ducts
Nephric Tubules
Neural Plate/Tube
Notochord
Paraxial Mesoderm
Sensory Organs
Somites
Stomach
Surface Ectoderm
Wing AER
Wing Mesenchyme

Rathoke's pouch

31-44

stage 44

Entry 3

GEISHA Id	NBL1.Singh.2016	Data Source	Publication
Complete cDNA Template Probe	show TGGGAACGTGGGCAGAGGGGGCTCTAGCAGAGAGCAGGAGCCAAGCTGGGCTCCCCAAGGGCTGTCTGCAGGATCCTTA GTCTGCTGTGGAGTCCTTGATGAGCCCTCTGGGATTTTCTTTTGTATGTGGCTCTTGCCTGGCCTGGAGAAAGAAGGGA CGCAGCTTCCCTGCAGCCACGCAAGAGATGCACATCTCTTCTGCGGCGTATGGGATGGGGGTCTCCCTTCTTCCTCACA CTTCCCCTGCCTGCCCAGGGGTGCCTGAGCTCAGCATGGGTGCTGTTCCTCCTGGCACTCACTGGGTCTTACTTCAACC CCCGTGCGTCGTGTTAGGTAGCTCATAGGGAGTATTTTGCCCTGGCTGTGCCTCCGGGGCTGTGTGTGAGGTTGCTGGG AGCCACGGTGGTCAGAGCCCTTTCCCTGCTGGTCCTCAGGGCCACCACATAGCTTGCAAGGGCGAGGGAGCTGCACTGT GTCATGGGCACTGGGGTTTCACGTTTCACAGCCCATGGTGGGGTGGCGTGGGTAGGAGCTGGCCCCTCTCCCCTCCTTC CCTGCTGCACTTTAATTGTGGTGGAGGGAGAAGGGAGACAAGTCCTGGGATGCTGATGGACCTCTGTAGGGGATTGCTC TGGACCCCACTGCAGATGCAGGGCTGGGCTCAGGGTGGGGGCCCCTCCTGCTACCCTCTCTCTGTNGTATAAAGCTAAT TTCTTGGGCACTGTCCTGACAAAAGCTTCCAGAGCTTGTAACCGATGCCTCCCTCTCCTTTTACAAGTTGGTAGGGTAA AGAGGATAAGTAAGTTTCTTAATAAATAGTCTGACTTCCA
Citation	Singh PN, Ray A, Azad K, Bandyopadhyay A. A comprehensive mRNA expression analysis of developing chicken articular cartilage. Gene Expr Patterns. 2016 Jan;20(1):22-31.
Copyright	Copyright © 2015 Elsevier B.V. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information provided in the publication as described in Singh et al. 2016. The probe was synthesized from cDNA clone ChEST634h24.