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TBX2 T-box 2Gene | Official Symbol | TBX2 | Official Full Name | T-box 2 | CGNC ID | 16508 | also known as | T-box transcription factor TBX2|T-Box protein 2, T-box transcription factor TBX2, T-box protein 2 | gene type | protein-coding |
| Genomic Map | | Sequence Information | | Gene Expression | | Orthology | | Entrez Gene | Ensembl Gene | Genetic Phenotypes | MOD | Fruit Fly | | | | | Human | | | | | Mouse | | | | | Xenopus | | | | | Zebrafish | | | | |
| Gene Ontology | Molecular Function | | Biological Process | | Cellular Component | |
| Links to other databases | |
Entry 1GEISHA Id | Tbx2.Plageman.2005 | Data Source | Publication | Complete cDNA Template Probe | show CTTTGGGACCAATTCCACAAGCTGGGCACCGAGATGGTGATCACCAAATCCGGGAGGAGGATGTTCCCCCCGTTCAAGG TGCGGGTGAGCGGCCTGGACAAGAAGGCCAAATACATTTTGCTCATGGATATAGTTGCGGCCGACGACTGCCGGTACAA ATTCCACAACTCCCGCTGGATGGTGGCCGGGAAGGCCGACCCGGAGATGCCCAAACGCATGTACATCCACCCCGACAGC CCGGCCACCGGCGAGCAGTGGATGGCCAAACCCGTTGCCTTTCACAAACTCAAGCTCACCAACAACATCTCGGACAAAC ACGGCTTTACCATCCTGAACTCCATGCACAAATACCAGCCCCGCTTCCACATCGTGCGGGCCAACGACATCCTCAAGCT GCCCTACAGCACCTTCCGCACCTACGTGTTCCCCGAGACCGACTTCATCGCCGTCACCGCCTACCAGAACGACAAGATC ACGCAGCTGAAAATCGATAACAACCCCTTCGCCAAAGGCTTTCGGGACACGGGCAACGGCCGTCGGGAGAAGA | Citation | Plageman TF, Yutzey KE. T-Box genes and heart development: Putting the "T" in HearT. Dev Dyn. 2005 Jan;232(1):11-20. | Copyright | Copyright © 2005 Wiley-Liss, Inc. |
Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | 31-36 |
| stage 36 | | Atria Heart Ventricles
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Entry 2GEISHA Id | Tbx2.Yamada.2000 | Data Source | Publication | Complete cDNA Template Probe | show ATGAGCGGCGCTCGGCCGAACCGCGGAGCGCGCAGCGGTGCGGAGCCCTCCGGGGCGCAGTCGGAGCCCGCGGGGCCGA ACCGCACACTGATTTTTTATTATTGTTGTTATTATTGTCGTTTTTTTGTTATTATTATTTTTTTTTTAACAAAAGGGAA TCCCTCTTTTTCTCCTGGATTTGTGGATGCACCGATGAGAGATCCAGCCTTCCCAGGGACTGCCATGGCTTACCACCCC TTCCACGCTCCCCGGCCGGCCGATTTCCCCATGTCCGCTTTCCTCGCCGCCGCTCAGCCCTCCTTTTTCCCCGCTCTGG CTCTGCCCCCGGCGGCTCTGGCCAAGCCCATGCCGGACCCGGGGCTGGCCGGGGCGGCCGAGGCCGGGCTGCACGTCTC GGCTCTGGGCCACCACCACCAGGCAGCCCATCTGCGCTCCCTCAAGAGCCTGGAGCCCGAGGAGGAGGTGGAGGACGAC CCCAAAGTGACGCTGGAAGCCAAAGAGCTTTGGGACCAATTCCACAAGCTGGGCACCGAGATGGTGATCACCAAATCCG GGAGGAGGATGTTCCCCCCGTTCAAGGTGCGGGTGAGCGGCCTGGACAAGAAGGCCAAATACATTTTGCTCATGGATAT AGTTGCGGCCGACGACTGCCGGTACAAATTCCACAACTCCCGCTGGATGGTGGCCGGGAAGGCCGACCCGGAGATGCCC AAACGCATGTACATCCACCCCGACAGCCCGGCCACCGGCGAGCAGTGGATGGCCAAACCCGTTGCCTTTCACAAACTCA AGCTCACCAACAACATCTCGGACAAACACGGCTTTACCATCCTGAACTCCATGCACAAATACCAGCCCCGCTTCCACAT CGTGCGGGCCAACGACATCCTCAAGCTGCCCTACAGCACCTTCCGCACCTACGTGTTCCCCGAGACCGACTTCATCGCC GTCACCGCCTACCAGAACGACAAGGTAGGGCTGGCAGCACCCGACCCCAACCCCTGTACCGACCCCCAGCGCCACGCAC CAACCCGAGCTCCTGCACCCCATCCCCTGCCCCTTTTTGGGTCTGTTTTCACGATGATGCCCAACCCGAACAGCTGCTG ACACAGAACAT | Citation | Yamada M, Revelli JP, Eichele G, Barron M, Schwartz RJ. Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2. Dev Biol. 2000 Dec 1;228(1):95-105. | Copyright | Reprinted with permission from Elsevier.
Copyright © 2000 Elsevier B.V. All rights reserved.
| Comments | Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (XM_001235320). |
Entry 3GEISHA Id | Tbx2.Nissim.2007 | Data Source | Publication | Complete cDNA Template Probe | show ATGAGCGGCGCTCGGCCGAACCGCGGAGCGCGCAGCGGTGCGGAGCCCTCCGGGGCGCAGTCGGAGCCCGCGGGGCCGA ACCGCACACTGATTTTTTATTATTGTTGTTATTATTGTCGTTTTTTTGTTATTATTATTTTTTTTTTAACAAAAGGGAA TCCCTCTTTTTCTCCTGGATTTGTGGATGCACCGATGAGAGATCCAGCCTTCCCAGGGACTGCCATGGCTTACCACCCC TTCCACGCTCCCCGGCCGGCCGATTTCCCCATGTCCGCTTTCCTCGCCGCCGCTCAGCCCTCCTTTTTCCCCGCTCTGG CTCTGCCCCCGGCGGCTCTGGCCAAGCCCATGCCGGACCCGGGGCTGGCCGGGGCGGCCGAGGCCGGGCTGCACGTCTC GGCTCTGGGCCACCACCACCAGGCAGCCCATCTGCGCTCCCTCAAGAGCCTGGAGCCCGAGGAGGAGGTGGAGGACGAC CCCAAAGTGACGCTGGAAGCCAAAGAGCTTTGGGACCAATTCCACAAGCTGGGCACCGAGATGGTGATCACCAAATCCG GGAGGAGGATGTTCCCCCCGTTCAAGGTGCGGGTGAGCGGCCTGGACAAGAAGGCCAAATACATTTTGCTCATGGATAT AGTTGCGGCCGACGACTGCCGGTACAAATTCCACAACTCCCGCTGGATGGTGGCCGGGAAGGCCGACCCGGAGATGCCC AAACGCATGTACATCCACCCCGACAGCCCGGCCACCGGCGAGCAGTGGATGGCCAAACCCGTTGCCTTTCACAAACTCA AGCTCACCAACAACATCTCGGACAAACACGGCTTTACCATCCTGAACTCCATGCACAAATACCAGCCCCGCTTCCACAT CGTGCGGGCCAACGACATCCTCAAGCTGCCCTACAGCACCTTCCGCACCTACGTGTTCCCCGAGACCGACTTCATCGCC GTCACCGCCTACCAGAACGACAAGGTAGGGCTGGCAGCACCCGACCCCAACCCCTGTACCGACCCCCAGCGCCACGCAC CAACCCGAGCTCCTGCACCCCATCCCCTGCCCCTTTTTGGGTCTGTTTTCACGATGATGCCCAACCCGAACAGCTGCTG ACACAGAACAT | Citation | Nissim S, Allard P, Bandyopadhyay A, Harfe BD, Tabin CJ. Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol. 2007 Apr 1;304(1):9-21. | Copyright | Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. | Comments | As insufficient information is provided in the publication to verify the exact sequence used to synthesize the probe, the sequence below was obtained from NCBI (acc # XM_001235320.1). |
Entry 4GEISHA Id | TBX2.Firnberg.2002 | Data Source | Publication | Complete cDNA Template Probe | show ATGAGCGGCGCTCGGCCGAACCGCGGAGCGCGCAGCGGTGCGGAGCCCTCCGGGGCGCAGTCGGAGCCCGCGGGGCCGA ACCGCACACTGATTTTTTATTATTGTTGTTATTATTGTCGTTTTTTTGTTATTATTATTTTTTTTTTAACAAAAGGGAA TCCCTCTTTTTCTCCTGGATTTGTGGATGCACCGATGAGAGATCCAGCCTTCCCAGGGACTGCCATGGCTTACCACCCC TTCCACGCTCCCCGGCCGGCCGATTTCCCCATGTCCGCTTTCCTCGCCGCCGCTCAGCCCTCCTTTTTCCCCGCTCTGG CTCTGCCCCCGGCGGCTCTGGCCAAGCCCATGCCGGACCCGGGGCTGGCCGGGGCGGCCGAGGCCGGGCTGCACGTCTC GGCTCTGGGCCACCACCACCAGGCAGCCCATCTGCGCTCCCTCAAGAGCCTGGAGCCCGAGGAGGAGGTGGAGGACGAC CCCAAAGTGACGCTGGAAGCCAAAGAGCTTTGGGACCAATTCCACAAGCTGGGCACCGAGATGGTGATCACCAAATCCG GGAGGAGGATGTTCCCCCCGTTCAAGGTGCGGGTGAGCGGCCTGGACAAGAAGGCCAAATACATTTTGCTCATGGATAT AGTTGCGGCCGACGACTGCCGGTACAAATTCCACAACTCCCGCTGGATGGTGGCCGGGAAGGCCGACCCGGAGATGCCC AAACGCATGTACATCCACCCCGACAGCCCGGCCACCGGCGAGCAGTGGATGGCCAAACCCGTTGCCTTTCACAAACTCA AGCTCACCAACAACATCTCGGACAAACACGGCTTTACCATCCTGAACTCCATGCACAAATACCAGCCCCGCTTCCACAT CGTGCGGGCCAACGACATCCTCAAGCTGCCCTACAGCACCTTCCGCACCTACGTGTTCCCCGAGACCGACTTCATCGCC GTCACCGCCTACCAGAACGACAAGGTAGGGCTGGCAGCACCCGACCCCAACCCCTGTACCGACCCCCAGCGCCACGCAC CAACCCGAGCTCCTGCACCCCATCCCCTGCCCCTTTTTGGGTCTGTTTTCACGATGATGCCCAACCCGAACAGCTGCTG ACACAGAACAT | Citation | Firnberg N, Neubüser A (2005).FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev Biol. 2002 Jul 15;247(2):237-50. | Copyright | "Reprinted from Developmental Biology, 247(2), Firnberg N, Neubüser A, FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region, 237-50., Copyright (2002), with permission from Elsevier".
Copyright © (2002) Elsevier B.V. All rights reserved. | Comments | According to authors, "The plasmids used to prepare the antisense riboprobes employed in this study have
previously been described: (see refs)." As information provided was insufficient to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # XM_001235320). |
Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | 13-18 | | stage 18 | | Face Mesenchyme
| 19-24 | | stage 24 | | Face Mesenchyme
| 31-44 | | stage 44 | | |
Entry 5GEISHA Id | TBX2.Manning.2007 | Data Source | Publication | Complete cDNA Template Probe | show CACCAACAACATCTCGGACAAACACGGCTTTACCATCCTGAACTCCATGCACAAATACCAGCCCCGCTTCCACATCGTG CGGGCCAACGACATCCTCAAGCTGCCCTACAGCACCTTCCGCACCTACGTGTTCCCCGAGACCGACTTCATCGCCGTCA CCGCCTACCAGAACGACAAGATCACGCAGCTGAAAATCGATAACAACCCCTTCGCCAAAGGCTTTCGGGACACGGGCAA CGGCCGTCGGGAGAAGAGGAAGCAGCTCTCGCTGCCGTCACTGCGGATGTACGAGGAGCCCTGCAAACCCGATCGAGAC GGCGGCGAATCGGACGCGTCTTCCTGCGAACCATCGGCGGTGCGCGACGCTCTGCACTCCCCCGTGGGCCCCCTCCCCA GCCCCCTGCGCCTGAAGGGCAGTGGCAGAGAGGAGAAGCCGGGGGCTGACAGTGATGCGGAGGTGGAGAAGGTGTCCGA GGAGCGGCCAGTGGGCGGCAGCCCCGGTAGGGAGGACACATCACCCCGTGGCAGCCCACGGTGCACCGACGAGCGGGGC AAGGAGAGGCACAGCCCGGAGAAAGCCAAGGATGGAGCATCCCCAGGGGACGGCCCCAGTGAGGGTCTGTTTGGCGCAC GGGGCATGGAGAAGGACAAAGTGGAAGGGAGGAGGAAAGAGCCGGAGCAGGGCAAGAAGGACGCAGAGGGGGTCGGGCT GGGCAAGGAGGCCTTTGCCCCGCTGATGGTGCACACGGACAGCCCTCCGCACCTGAGCGCCGGGCACCTGCAGAGCCTC GCGCTCTCTGGGCTCCACGGGCAGCAGTTCTTCAGCCCGCTGGGTGCTGGGCAGCCACTCTTCATCCACCCGGGACAGT TCGCCATGGCCCCCGGGGCTTTCTCCGCTATGGGCATGGGACATTTGCTGGCCTCGGTGACCGGCGGCGGCAGCCTGGA GAACGGGGCACTCTCGTCCACCCCAGGCGCAGCGGGGACAGCCACCCCCTTCCCATTCCACCTCTCCCAGCACATGCTG GCTTCTCAGGGAATCCCGATGCCCACTTTCGGCGGCCTCTTCCCCTACCCCTACACCTACATGGCAGCAGCAGCAGCAG CCGCCTCGGCCATGCCGGCCACCAGCGCAGCCGCCGCCGCCGCCGGGCCGCTGTCCCGCAATCCCTTCCTGGGCAGCAG CCGCCCCCGCCTGCGCTTCAGCCCCTACCAGCTCCCGGTCAGCATCCCACCCAGCACCAACCTGCTCACCACCGGCCTC CCCTCCAGCCTCAACCCCAGCTCCGAGGGCTCCAAGGCGGGCAGCAGCCGTGAGCCCAGCCCCATCCCCGACGTGCACA AAGCCCATCGCCCCTCTGCCTCCCCTCCCAAAGGTTCCCTGAAGGAATCCCTCAACGAACTGCAGAACATCCAGAGACT GGTGAGCGGGCTGGAGAGCCAGCGGGAGCTGTCGCCCGGCAGGGAGTCCCCCAAGTGACCACGGGGACAGGCAGCGCAC CC | Citation | Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M, Placzek M. Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev Cell. 2006 Dec;11(6):873-85. | Copyright | Copyright © 2006 Elsevier Inc. All rights reserved. | Comments | The probe was amplified by PCR using the following primers:
5'-CACCAACAACATCTCGGACAAA-3' and 5'-GCCTGGACAAGAAGGCCAAATA-3' and was extracted from NCBI Acc# XM_001235320.3. |
Stage | Image (click image to view full size) | Location (click to highlight) | Comments (click to highlight) | 7-12 | | stage 10 | | stage 12 | | Hypothalamus
| 13-18 | | stage 13 | | stage 14 | | stage 15 | | stage 16 | | stage 16 | | Diencephalon Hypothalamus
| 19-22 | | stage 22 | | stage 22 | | Diencephalon
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Entry 6GEISHA Id | Tbx2.Gibson-Brown.1998 | Data Source | Publication | Complete cDNA Template Probe | show AAAAAAGATAAAAATAATCAAGCCGAACCGCACACTGATTTTTTATTATTGTTGTTATTATTGTCGTTTTTTTGTTATT ATTATTTTTTTTTTAACAAAAGGGAATCCCTCTTTTTCTCCTGGATTTGTGGATGCACCGATGAGAGATCCAGCCTTCC CAGGGACTGCCATGGCTTACCACCCCTTCCACGCTCCCCGGCCGGCCGATTTCCCCATGTCCGCTTTCCTCGCCGCCGC TCAGCCCTCCTTTTTCCCCGCTCTGGCTCTGCCCCCGGCGGCTCTGGCCAAGCCCATGCCGGACCCGGGGCTGGCCGGG GCGGCCGAGGCCGGGCTGCACGTCTCGGCTCTGGGCCACCACCACCAGGCAGCCCATCTGCGCTCCCTCAAGAGCCTGG AGCCCGAGGAGGAGGTGGAGGACGACCCCAAAGTGACGCTGGAAGCCAAAGAGCTTTGGGACCAATTCCACAAGCTGGG CACCGAGATGGTGATCACCAAATCCGGGAGGAGGATGTTCCCCCCGTTCAAGGTGCGGGTGAGCGGCCTGGACAAGAAG GCCAAATACATTTTGCTCATGGATATAGTTGCGGCCGACGACTGCCGGTACAAATTCCACAACTCCCGCTGGATGGTGG CCGGGAAGGCCGACCCGGAGATGCCCAAACGCATGTACATCCACCCCGACAGCCCGGCCACCGGCGAGCAGTGGATGGC CAAACCCGTTGCCTTTCACAAACTCAAGCTCACCAACAACATCTCGGACAAACACGGCTTTACCATCCTGAACTCCATG CACAAATACCAGCCCCGCTTCCACATCGTGCGGGCCAACGACATCCTCAAGCTGCCCTACAGCACCTTCCGCACCTACG TGTTCCCCGAGACCGACTTCATCGCCGTCACCGCCTACCAGAACGACAAGATCACGCAGCTGAAAATCGATAACAACCC CTTCGCCAAAGGCTTTCGGGACACGGGCAACGGCCGTCGGGAGAAGAGGAAGCAGCTCTCGCTGCCGTCACTGCGGATG TACGAGGAGCCCTGCAAACCCGATCGAGACGGCGGCGAATCGGACGCGTCTTCCTGCGAACCATCGGCGGTGCGCGACG CTCTGCACTCCCCCGTGGGCCCCCTCCCCAGCCCCCTGCGCCTGAAGGGCAGTGGCAGAGAGGAGAAGCCGGGGGCTGA CAGTGATGCGGAGGTGGAGAAGGTGTCCGAGGAGCGGCCAGTGGGCGGCAGCCCCGGTAGGGAGGACACATCACCCCGT GGCAGCCCACGGTGCACCGACGAGCGGGGCAAGGAGAGGCACAGCCCGGAGAAAGCCAAGGATGGAGCATCCCCAGGGG ACGGCCCCAGTGAGGGTCTGTTTGGCGCACGGGGCATGGAGAAGGACAAAGTGGAAGGGAGGAGGAAAGAGCCGGAGCA GGGCAAGAAGGACGCAGAGGGGGTCGGGCTGGGCAAGGAGGCCTTTGCCCCGCTGATGGTGCACACGGACAGCCCTCCG CACCTGAGCGCCGGGCACCTGCAGAGCCTCGCGCTCTCTGGGCTCCACGGGCAGCAGTTCTTCAGCCCGCTGGGTGCTG GGCAGCCACTCTTCATCCACCCGGGACAGTTCGCCATGGCCCCCGGGGCTTTCTCCGCTATGGGCATGGGACATTTGCT GGCCTCGGTGACCGGCGGCGGCAGCCTGGAGAACGGGGCACTCTCGTCCACCCCAGGCGCAGCGGGGACAGCCACCCCC TTCCCATTCCACCTCTCCCAGCACATGCTGGCTTCTCAGGGAATCCCGATGCCCACTTTCGGCGGCCTCTTCCCCTACC CCTACACCTACATGGCAGCAGCAGCAGCAGCCGCCTCGGCCATGCCGGCCACCAGCGCAGCCGCCGCCGCCGCCGGGCC GCTGTCCCGCAATCCCTTCCTGGGCAGCAGCCGCCCCCGCCTGCGCTTCAGCCCCTACCAGCTCCCGGTCAGCATCCCA CCCAGCACCAACCTGCTCACCACCGGCCTCCCCTCCAGCCTCAACCCCAGCTCCGAGGGCTCCAAGGCGGGCAGCAGCC GTGAGCCCAGCCCCATCCCCGACGTGCACAAAGCCCATCGCCCCTCTGCCTCCCCTCCCAAAGGTTCCCTGAAGGAATC CCTCAACGAACTGCAGAACATCCAGAGACTGGTGAGCGGGCTGGAGAGCCAGCGGGAGCTGTCGCCCGGCAGGGAGTCC CCCAAGTGACCACGGGGACAGGCAGCGCACCCGCCCCCCCTCCCCGGGGCTGAGAAGCACTGGTCTTTTGTACAGCACA GTATAAATATTTATTAAAGGTGGGGACGGATGGGGAGAGGGCTCTCCCAAATAGCCGCCCCCTCCCCCCCACCCCCGAG TGCCACCCCCCCATCCCTGCTCCCCGCCGCGGGGCACGGGGCTGCCCTACGTGCGCTGTTGGACAGGGCGGGCGGAGCG GCCGTGGGGCTGAGACCTCCGTGCAAAGGGCGGTGGGGGGGGGGGGGGGGGGAGGGAAGGGGAGGAAGGAGGAAAAACT AAACACAAAGGAAAAGAAGAAGCGAAGCATGGAATGGAGCCGCCTTGGAGCTGCGCTGCCACCGCCACGCAGGGAGCGA GCGGCAGGGCAGATATTTATGAAATAAATGGTAATTTGTGTACATAAGCTATAAGGATCCCAGAATATGCAAATTGGTA TTAATTTATTCAGAGTTGTACATTGGTGTGTACATAATATTTAGAGTTTAACTCATCGCATTTAAGTTTTCTGTTGGTT TTTTTTTTTTTTTTCCATTTTACATGAACATATATATTGTAAATGAAAACTATTTAGCTCTTTGTGATTGAAGGAGATA TTGGTTTCTTTAACTGTGTTTAAAATATTGTTTATCCCTCCTGCTCTCCAGGACAATCAGTGCCACCGGTACCGCAATG TTTGGAGTCATTGGAACCAAGAGTTCAATTCTTTAATGGACTTTTGCAAGGAAATAATAATTATAGTAATAACAAATCA AATCCAAAATGTAGGAAAGTGTCTCTCCAGAGCGGGGTATGCAGAATGCAGGAATAAACCTCAGGTTTTTATTTTTCAC TCCAGAACAAAGCAAAACAGCAACAATAAAAGAAGAAGTATAATAAATCTAAATATCACAGGACTGTGCTCTATATTTG TTTTAAAATAAAAAGATACAATGATTTGAAAGGTG | Citation | Gibson-Brown JJ, I Agulnik S, Silver LM, Papaioannou VE. Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech Dev. 1998 Jun;74(1-2):165-9. | Copyright | Copyright © 1998 Elsevier Science Ireland Ltd. | Comments | Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (XM_001235320). |
| Data from NCBI Unigene EST Profile Unigene ID: Gga.964 |
MouseFrogFruit FlyZebra FinchZebrafish
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