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FECH
ferrochelatase

The human orthologue of this gene is associated
with the following human disease:

Gene

Official Symbol	FECH
Official Full Name	ferrochelatase
CGNC ID	2220
also known as	ferrochelatase, mitochondrial\|ferrochelatase (protoporphyria)\|heme synthase\|heme synthetase\|protoheme ferro-lyase
gene type	protein-coding

Genomic Map

Sequence Information

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.166

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	43757			FBgn0024891
Human	2235	ENSG00000066926	MIM:177000	MIM:612386
Mouse	14151	ENSMUSG00000024588	All phenotypic alleles (2):Chemically induced(1) Targeted, knock-out(1)	MGI:95513
Xenopus	100496154, 398014			960753
Zebrafish	58215	ENSDARG00000003462	ZDB-GENE-000928-1	ZFIN:ZDB-GENE-000928-1

Gene Ontology

Molecular Function	2 iron, 2 sulfur cluster binding, ferrochelatase activity, metal ion binding
Biological Process	heme biosynthetic process, heme metabolic process, small molecule metabolic process
Cellular Component	mitochondrial inner membrane, mitochondrial matrix

Links to other databases

GEISHA Id	FCH.Nakazawa.2009	Data Source	Publication
Complete cDNA Template Probe	show AGGCTGGATGATGTGCATGACTTCTTGCTGCGCCTCTTCCTGGACCGGGACCTCATGACGCTTCCAGCACAAAATAAAC TTGCACCGTTCATCGCTAAACGCCGCACACCACGAATTCAGGAGCAGTACAGCAGGATTGGAGGGGGGTCACCCATCAA GAAGTGGACGGCGGTGCAGGGAGAAGGCATGGTGAAACTGCTGGACAGCATGTCTCCTCAGACCGCACCCCACAAGTAC TACATTGGCTTCCGGTACGTGCACCCTCTGACAGAGGAAGCAATTGAGGAGATGGAGGATGACGGCATCGAGAGAGCCA TCGCCTTCACGCAGTACCCGCAGTACAGCTGCTCCACCACAGGAAGCAGCTTAAATGCCATTTATCGCTACTACAATAA AAAGGGGAAGAAGCCAAAGATGAAGTGGAGTATCATTGACCGATGGCCCACACACCCCCTGCTCATCCAGTGCTTTGCC GATCACATACAGAAGGAGCTGGACCTGTTCCCACCTGACAAAAGGAAAGATGTCGTCATCCTTTTCTCAGCCCACTCGC TCCCCATGTCTGTGGTGAACCGTGGTGATCCGTATCCACAAGAAGTGGGAGCTACTGTCCAGAGAGTCATGGAGAAGCT GAACCACTCCAACCCCTACCGGCTGGTCTGGCAGTCCAAGGTTGGGCCAATGCCTTGGCTTGTTCCACAAACAGACGAG ACGATTAAAGGACTGTGCCAAAGAGGAAAGAAGAACATGTTGTTGGTCCCCATAGCATTTACAAGTGACCACATTGAAA CGCTTTACGAACTGGATATTGAGTATGCCCAAGTTTTAGCAAACGAGTGTGGCGTTGAGAACATCAGAAGAGCGGAGTC ACTTAATGGAAACCCACTGTTCTCCAAGGCTCTGGCAGACTTGGTCTGCTCACACATCCAGTCCAATGAGATCTGC
Citation	Nakazawa F, Alev C, Shin M, Nakaya Y, Jakt LM, Sheng G. PBRL, a putative peripheral benzodiazepine receptor, in primitive erythropoiesis. Gene Expr Patterns. 2009 Feb;9(2):114-21. Epub 2008 Sep 25. DIO: 10.1016/j.gep.2008.09.005.
Copyright	Copyright © 2008 Elsevier B.V.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Nakazawa et al. 2009. Also known as: FECH