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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PHOX2B
paired like homeobox 2b

The human orthologue of this gene is associated
with the following human diseases:

Gene

Official Symbol	PHOX2B
Official Full Name	paired like homeobox 2b
CGNC ID	49370
also known as	paired mesoderm homeobox protein 2B, Phox2b protein
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	XM_001234150
Polypeptide	XP_001234151
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.10503

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	8929	ENSG00000109132	MIM:209880	MIM:603851
Mouse	18935	ENSMUSG00000012520	All phenotypic alleles (6):Chemically induced(1) Targeted, other(5)	MGI:1100882
Xenopus	100124329, 495120			1000414
Zebrafish	544654, 795258	ENSDARG00000091029, ENSDARG00000075330	ZDB-GENE-050407-3, ZDB-GENE-090313-51	ZFIN:ZDB-GENE-050407-3, ZFIN:ZDB-GENE-090313-51

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395548
Ensembl Gene
KEGG	gga:395548

Entry 1

GEISHA Id	ChEST47n21	Data Source	GEISHA ISH Analysis
Forward cDNA Template Probe	show `AGAGCCTTTTCAATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACA CCTCGAGCCTGGCTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGAC CACTTTCGGGGCCACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGC AGCCCCTACGCAGCAGGTAAGGACCTCCGGCTTTCTTACCCCGGCAGCCGCCTCGCCGCTGGTATATAGGAAGCCTTGA TTGCATTTGAAAATGGAAATGTGTTTAGTATTTACCAAACGAAATTTGCTTACACAAATGAAAGAATTTATCACGTTAG AAGCGATTGCAGGGAGGGGTAATTCACTTACAGGGTTACACTATCCTAGTCACACCCGAACCGCC`

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 9

13-18

stage 14

stage 18

Foregut
Heart
Hindbrain
Pharyngeal Arches and Clefts
Spinal Cord
Spinal Ganglia and Nerves
Splanchnic Mesoderm

hand transected

19-20

stage 20

Hindbrain

Entry 2

GEISHA Id	PHOX2A.Agarwala.2001	Data Source	Publication
Complete cDNA Template Probe	show ATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGG CTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGC CACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCA GCAGTTCCTTACAAACTCTTCACCGACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCA CCAGCGCGCAGCTCAAGGAACTGGAGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGC GCTCAAGATCGACCTCACCGAGGCCCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCTGGAGCGG GCGGCGGCGGCGGCGGCGGCGGCCGCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCA AGGAGGCCAAGAGCACCGACCCCGACAGCACCGGCGGCCCCGGGCCCAACCCCAACCCCGCGCCCAGCTGCGGCGGCGG CGGCGGGCCCAGCCCCGCGGGCGGGCAGGGGGCGGTGGGGCCCGGCGGCCCGGGTTGAGAGCCGGGTGGAGCGGCGGAC CTCAGAACAACTCAGCCCATCAGCGGGATGCTGCACAACCAGGAAAGCTTCACCGTAACCATCGCGCTGCAGCTCACAG ACTCACAAGGCATTGTGTCCGCCCACTCCGCAGCCTCCCCCCGCATCACCCCGTCCTTAAACCTCATAACAACACTGGC TTCTGAACCTGCTGAGGAGGATTGCTCCTGA
Citation	Agarwala S, Sanders TA, Ragsdale CW. Sonic hedgehog control of size and shape in midbrain pattern formation. Science. 2001 Mar 16;291(5511):2147-50. Epub 2001 Mar 1.
Copyright	© 2011 American Association for the Advancement of Science. All Rights Reserved.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_001234150)

Stage

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Location (click to highlight)

Comments (click to highlight)

25-26

stage 26

Midbrain

multiple probes

Entry 3

GEISHA Id	PHOX2B.Huber.2008	Data Source	Publication
Complete cDNA Template Probe	show ATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGG CTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGC CACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCA GCAGTTCCTTACAAACTCTTCACCGACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCA CCAGCGCGCAGCTCAAGGAACTGGAGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGC GCTCAAGATCGACCTCACCGAGGCCCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCTGGAGCGG GCGGCGGCGGCGGCGGCGGCGGCCGCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCA AGGAGAATTGGGGAACAAAGCGCAGACCGCCCCGTCTGTCAGAGGTGCCGCGCCCCCGGGCTGCCCCCACCGACCCGCG GAAGGCGACGGCTGCTCAGGGCCCGGGAGCTGCCGCGGCCCCGACGGGGCGGGCGGAGCGCGGCCCCGGCGCTGCCGGG ACAGCCTCGCAACCCGCCGCTCCCGGGGGCACGGCGGGGTGA
Citation	Huber K, Franke A, Brühl B, Krispin S, Ernsberger U, Schober A, von Bohlen und Halbach O, Rohrer H, Kalcheim C, Unsicker K. Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development. Neural Dev. 2008 Oct 22;3:28.
Copyright	© 2008 Huber et al; licensee BioMed Central Ltd. (requested from Dr. Unsicker)
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_001234150.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-18

stage 15

stage 16

stage 17

stage 18

Intermediate Mesoderm
Spinal Ganglia and Nerves

19-21

stage 21

Spinal Ganglia and Nerves

Entry 4

GEISHA Id	PHOX2B.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show ATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGG CTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGC CACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCA GCAGTTCCTTACAAACTCTTCACCGACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCA CCAGCGCGCAGCTCAAGGAACTGGAGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGC GCTCAAGATCGACCTCACCGAGGCCCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCTGGAGCGG GCGGCGGCGGCGGCGGCGGCGGCCGCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCA AGGAGAATTGGGGAACAAAGCGCAGACCGCCCCGTCTGTCAGAGGTGCCGCGCCCCCGGGCTGCCCCCACCGACCCGCG GAAGGCGACGGCTGCTCAGGGCCCGGGAGCTGCCGCGGCCCCGACGGGGCGGGCGGAGCGCGGCCCCGGCGCTGCCGGG ACAGCCTCGCAACCCGCCGCTCCCGGGGGCACGGCGGGGTGA
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # XM_001234150.2).

Stage

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Location (click to highlight)

Comments (click to highlight)

25-30

stage 27

stage 29

stage 30

Esophagus
Head Mesenchyme
Neural Plate/Tube
Spinal Ganglia and Nerves

ciliary ganglia
control embryo
enteric ganglia

31-34

stage 31

stage 34

Cranial Ganglia
Esophagus

control embryo
enteric ganglia

Entry 5

GEISHA Id	PHOX2B.WatariGoshima.2011	Data Source	Publication
Complete cDNA Template Probe	show ATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGG CTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGC CACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCA GCAGTTCCTTACAAACTCTTCACCGACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCA CCAGCGCGCAGCTCAAGGAACTGGAGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGC GCTCAAGATCGACCTCACCGAGGCCCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCTGGAGCGG GCGGCGGCGGCGGCGGCGGCGGCCGCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCA AGGAGAATTGGGGAACAAAGCGCAGACCGCCCCGTCTGTCAGAGGTGCCGCGCCCCCGGGCTGCCCCCACCGACCCGCG GAAGGCGACGGCTGCTCAGGGCCCGGGAGCTGCCGCGGCCCCGACGGGGCGGGCGGAGCGCGGCCCCGGCGCTGCCGGG ACAGCCTCGCAACCCGCCGCTCCCGGGGGCACGGCGGGGTGA
Citation	Watari-Goshima N, Chisaka O. Chicken HOXA3 Gene: Its Expression Pattern and Role in Branchial Nerve Precursor Cell Migration. Int J Biol Sci. 2011; 7(1): 87101. Published online 2011 January 19.
Copyright	Copyright © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_001234150.2 ).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-15

stage 15

Cranial Nerve

Entry 6

GEISHA Id	PHOX2B.Howard.2000	Data Source	Publication
Complete cDNA Template Probe	show ATGTATAAAATGGAATATTCTTACCTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGG CTTCAGCGTATGCTGACTTCAGTTCCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGC CACCTCAGGCTGCCCGTCCCTCACTCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCA GCAGTTCCTTACAAACTCTTCACCGACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCA CCAGCGCGCAGCTCAAGGAACTGGAGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGC GCTCAAGATCGACCTCACCGAGGCCCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCTGGAGCGG GCGGCGGCGGCGGCGGCGGCGGCCGCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCA AGGAGAATTGGGGAACAAAGCGCAGACCGCCCCGTCTGTCAGAGGTGCCGCGCCCCCGGGCTGCCCCCACCGACCCGCG GAAGGCGACGGCTGCTCAGGGCCCGGGAGCTGCCGCGGCCCCGACGGGGCGGGCGGAGCGCGGCCCCGGCGCTGCCGGG ACAGCCTCGCAACCCGCCGCTCCCGGGGGCACGGCGGGGTGA
Citation	Howard MJ, Stanke M, Schneider C, Wu X, Rohrer H. The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 2000 Sep;127(18):4073-81.
Copyright	Copyright is held by the authors. Published by The Company of Biologists, Ltd.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI XM_001234150.2

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 18

Spinal Cord
Spinal Ganglia and Nerves

HH Stage 18+

19-24

stage 19

Cranial Ganglia

31-34

stage 34

Entry 7

GEISHA Id	PHOX2b.Freter.2012	Data Source	Publication
Complete cDNA Template Probe	show AACACTTGGATTCGCATCATTCTTTGGTGCCCTTTAGATTTGGGGGACGGAAGACAGATGTTGGCAGCGCCTTTCTCCT CTTGTCTGCCGGCCATAAAGGGAGGACCATTTAGAGCCCGCAATTTGTTTCCGCCCTCGCACTAAAACCGTGTTCACAT TTATTTTCATTTCGCCGGTGCACAAAAAGTGTCCACGGGCCACCAAAGGCCGTTCTTTATCAAATACACATTGTACAAC ATGCAGCCGCAATAAAGCCGTCAGCTCTCGCCATAAAGCCCTCACCCGGCCCCTCAGAGGCTCGAGAATCTTTCGCGTC GTTTTATTGCCCCCCGGTAACTCACAGCGACGTGCCCCAAAATACTGCTGCCATTGAGTACCGCCTGATGTGGGGCGAA GCGGCGCGATGGGCAGCCTCGGCATGAGCACTGAGCTCGGCAAACGCTGCGCGTGCCTAAACGCCCCTATAAAGACCTT ATGACTTTGTTACTTTAATTGCCGACTTGTTACGGAGCACATAAACGGGGTAATGAATGTAATAAAACTAATTATCCAC ACATTCAAATCATATAAAATATCCTCTATTTGCTTATGCGGCGGCGAAGTTTAGCCGAGCGTTCTACGCTGCCCACCGA GAGGAAGGACTTAATGAAACCCAGATAACCGCCCGGCGATCGCAGCACTGCTGGCACCGTCCGCTGCGCGCATCCTGCG CGGTGCCTGCGCGGTGCCTGGGCGGTGCCTGCAGGTGTTGGTCCCTCGCGGGTGCGCGTGTGTCGCTCGGGCTCGGAGC CCCGTCCCAGCGCACTGCTTGCTTTGTGGCTCTTCTTCTCCTCCTCTCTCCCGCAGGAAGGAAAAATGGGCGCAAACCG GGATGAGCTGCGACGCGCGCACAGACCCCGCGCGGATCGCTGTTGCCATCCCAATATAAACGCTAATCACGATCAATAT CAATAACGACAATTTAATAAAGCCTTCCGTGCGGGCGAACGAACGAACGAAAGCCGCGGCTCCGAGCCCTAAGAACGCA CCTACGCGCAGTCCGGCGAGCGGCTCTATTCGTTGCCCTGCGCTAAAAATCCCGCAGCCACAATGCGGTGCAGGGACCC AACGGGAGGGCGCACGGCAACGCGGCAGCGCGCAGCCCCGGGGCAGAAGCGCAGTTCCCCCCAGACAGGTGGGTGTAAG GAAGCAGCTCCGAAAAGGAAAGGAGAAAAAAAAAAAAAAAGAAGAAGAAAAAAAGAAAAAGAAAAAAAAAAAAGCAGCC CACTGCCCACTTGGTCTATTTTACAGGGTGCCCGCGCCTGTTAATGTCCCGCTCCTTTATAGCATTTCATGCACTTCGG GGGGTAGAGTTGTTGTTAAATTGAGCGTGTAACGCTCTTACAAAACAGGTTTCTCGATGACATCAAGGTTTGTCTCCCG AACCGAGAGCGCACACACAATAAAAATAAATAAATCCCCCGCGGGAGGGGGGCGGCGGGGAACCACACCGTCTCAATTT ATGCCTAAGGTATATGATCAGTTAAAAAGGCTTAAAAGCACGGGCAAATTGGATCAGGGAGAATCGTCACCCAACTTTC ATTATTTCCAAGTAGTGTGATTGAATTAAAGGGCAGGGAGCTGGTTAGAAGGGAGGATCGAGGGGCTCGGTGCGTAATG GTGCGGTATTAAATTCTAATTAGAGATGCAGGAATCAGCGATAGGGAGGTTGGACAGCTCGGTCCCCCAGTGCCAGCCC AATAGACTGATGAGTTATTGTCATGTAAAAAGCGCCAGCAATAAGACCAACCGCTTTGCTATTGTCCAAGTGGAAAGAG CCAAGTTTATTATGAGGACTATATGCTCTAGAGACCTCAGGCAAGGCATCTCATAGGAGGCTTTTTCATAAAACTAGGC TCTGCTGGTAGTAGGGAGGCCACTCTCGAAGCGGGCGTTGAGCTGTGCACATCTCCCCACCACAGGCACCTTCTCCACA TAGCCAGCTCCGGTCTCATTTCTTCCACTTGGCTGAGCCATCCAGAGCCTTTTCAATGTATAAAATGGAATATTCTTAC CTCAATTCCTCCGCCTACGAGTCCTGTATGGCCGGGATGGACACCTCGAGCCTGGCTTCAGCGTATGCTGACTTCAGTT CCTGCAGCCAAGCCAGTGGCTTCCAGTATAACCCCATAAGGACCACTTTCGGGGCCACCTCAGGCTGCCCGTCCCTCAC TCCAGGATCCTGCAGCCTCGGCTCGCTCAGGGACCACCAGAGCAGCCCCTACGCAGCAGTTCCTTACAAACTCTTCACC GACCACGGCGGTTTGAACGAGAAGCGGAAACAGCGGCGGATCCGCACCACGTTCACCAGCGCGCAGCTCAAGGAACTGG AGCGGGTGTTCGCGGAGACGCACTACCCCGACATTTACACCCGGGAGGAGCTGGCGCTCAAGATCGACCTCACCGAGGC CCGAGTGCAGGTGTGGTTCCAGAACCGCCGCGCCAAGTTCCGCAAGCAGGAGCGGGCGGCGGCGGCGGCGGCGGCGGCC GCCAAGAACGGAGCGGCCGGCAAGAAGTCGGACGCCTCCCGCGACGACGAGAGCAAGGAGGCCAAGAGCACCGACCCCG ACAGCACCGGCGGCCCCGGGCCCAACCCCAACCCCGCGCCCAGCTGCGGCGGCGGCGGCGGGCCCAGCCCCGCGGGCGG GCAGGGGGCGGCGGGGCCCGGCGGCCCGGGGGGAGAGCCGGGCAAAGGGGCGGCGGGGCCCGGCGGGCTGGCGGCGGCG GGGCCGGGGCAGGGCTGGGCCCCGGGGCCCGGGCCCATCACCTCCATCCCCGACTCGTTAGGCGGCCCCTTCGCCAGCG TGCTCTCCTCGCTGCAGCGGCCCGGCGGCACCAAAGGCAGCCTCGTCAAGAGCGGCATGTTCTGAGCGGCGGCGGCGGC GGCCCCTCCCGCTCCGCGGTCCCCGCCGCCCCGC
Citation	Freter S, Muta Y, O'Neill P, Vassilev VS, Kuraku S, Ladher RK. Pax2 modulates proliferation during specification of the otic and epibranchial placodes. Dev Dyn. 2012 Nov;241(11):1716-28
Copyright	Copyright © 2012 Wiley Periodicals, Inc.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (XM_015285470.2).