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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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TH
tyrosine hydroxylase

The human orthologue of this gene is associated
with the following human disease:

Segawa syndrome, recessive

Gene

Official Symbol	TH
Official Full Name	tyrosine hydroxylase
CGNC ID	4940
also known as	tyrosine 3-monooxygenase, tyrosine hydroxylase, TH
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_204805
Polypeptide	NP_990136
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.327

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	38746			FBgn0005626
Human	7054	ENSG00000180176	MIM:605407	MIM:191290
Mouse	21823	ENSMUSG00000000214	All phenotypic alleles (16):Targeted, knock-out(4) Targeted, other(12)	MGI:98735
Xenopus	100488900, 100037248			992304
Zebrafish	30384	ENSDARG00000030621	ZDB-GENE-990621-5	ZFIN:ZDB-GENE-990621-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395592
Ensembl Gene	ENSGALG00000006551
KEGG	gga:395592

Entry 1

GEISHA Id	TH.Agarwala.2005	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21.
Copyright	Copyright © 2005 Elsevier Inc. All rights reserved.
Comments	According to the authors, "Digoxigenin (DIG)- and fluorescein-labeled riboprobes were synthesized from chick cDNA plasmids..." As information provided was insufficient to verify exact sequence used to synthesize probe,the sequence below was obtained from NCBI (NM_204805).

Stage

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Location (click to highlight)

Comments (click to highlight)

25-28

stage 28

Midbrain

1st arc
Midbrain Dopaminergic Neurons

Entry 2

GEISHA Id	TH.McPherson.2000	Data Source	Publication
Complete cDNA Template Probe	show CCTCGTGGAAGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCCGCTAAAGGCTTCCGCAGGGCGGTGTCGGAGC TGGACTCCAAGCAAGCTGAAGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTGAAGATGCCAGGAA GGAACGAGAGGCTGCAGCTGCAGCCACTGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGAGAAGGATGGGAGA GCCATGCTGAACCTATTCTTCATGCTCAAGGGTGTCAAGACCTCTCCACTCTCGCGAGCACTTAAGGTATTTGAGACAT TTGAAGCTAAAATCCACCACTTAGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAACTGGAATATTTTGT GCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAAAGGGTAGCAGAAGATGTGAGGACCACC AAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAATTGGACAAGTGCCATCATTTGGTCACCAAGTTTGACC CTGATTTGGACTTAGACCACCCGGGCTACTCTGATCAGGTATATCGCCAGAGGAGGAAATCAATAGCAGAAATTGCTTT TCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAAGGAGGTGTACAGT ACTCTGAAAAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTGCTGGAGAAATTCTGTGGCT ACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAAAGGACTGGATTCCAGCTGCGGCCTGT GCGTGGCCTGTTGTCTGCACGTGACTTCCTTGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACAGTATATCCGCCAC GCATCTTCACCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTGCTGGGCCATGTCCCAATGCTGGCTGACAAGA CATTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGAAACTGGCAACACT TTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGGGCTCCTGTCTTCA TACGGGGAGCTGATACACTCCTTGTCAGATGAACCAGAGGTACGGGACTTTGATCCTGACGCTGCTGCCGTTCAGCCCT GCCAGGACCAGCCCTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGCTGAGGAACTATGC AGCACATATCAAGCGGCCCTTCTCAGTGAAATACGAGCCGTACACCCACAGCATCGAGCTCCTGGACAGCCCCCAGACC ATCTGCCACTCCCTGGAGAGTGTAAGGGATGAGCTTCATACACTGATTAACGCGCTCAATGTGATCAGTTAATAAGCGA ACTGTGCTCTTCCATTCCCCTCTGCCCTCCCCTGCCTAGCCTGTAACTTTTACCTGTTGTCTCCAAACATTTGCACTGC TACCTGTCCCCCTGCTACCCCAACAGTTTCCCACATTGAATGTAGGGCCAGCTCAGAGGAAGGCAGAGAGACAAACCCA AGTCCTGTGGCATCTTAAGTGCTTTGCCTTTGACTGCTGGGAGAGGCTTAACAAAGTCTAAAGATAGAGGTCAGGCTAC AAAGTTGAAGTCAAGAGTTGTGGTCTAGGCCCCTGGATACAGCTCCTACCTGTTACAGCTTTTTGCACTTAAAAAAATG CAGAGCTGTTCAGGAACACTTCTGCTGGAATCAAGATCATGAGATTTAAGATTTCAGCTCTCACCTTCCCCTCAGCTTC TTGTGCATGAGCTCCTGAGCTCACACCTCACAAGGACACAAAAAGCACTACAATATCCTTGAAATTATATATTGACCTA AACCAGCAGGCTATCTGCCTAGTACAGAGGAGCATCCACCTACCTGCATTCTCCCCATCTCAACCACCATAAACGAATC CCAAACTCAAAGGAAAAACCGTA
Citation	McPherson CE, Varley JE, Maxwell GD. Expression and regulation of type I BMP receptors during early avian sympathetic ganglion development. Dev Biol. 2000 May 1;221(1):220-32.
Copyright	Reprinted with permission from Elsevier. Copyright © 2000 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe for quail TH mRNA. Sequence below was obtained from NCBI (M24778). Gene map shown is from chick TH gene (NP_990136.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

19-23

stage 23

Spinal Ganglia and Nerves

Figure 2 compares the expressions of BMP-4, BMPR-IA, BMPR-IB, and TH mRNAs
Quail
Sympathetic Ganglia

Entry 3

GEISHA Id	TH.Lee.2005	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	Lee VM, Bronner-Fraser M, Baker CV. (2005) Restricted response of mesencephalic neural crest to sympathetic differentiation signals in the trunk. Dev Biol. 2005 Feb 1;278(1):175-92.
Copyright	Copyright © 2004 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204805).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-30

stage 29

Cranial Ganglion

Ciliary Ganglion

31-34

stage 34

Cranial Ganglion

Ciliary Ganglion

Entry 4

GEISHA Id	TH.Agarwala.2002	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	Agarwala S, Ragsdale CW. A role for midbrain arcs in nucleogenesis. Development. 2002 Dec;129(24):5779-88.
Copyright	Published by The Company of Biologists 2007. This material is protected by a copyright retained by the authors. Permission granted by Dr. Ragsdale.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204805.1) Two-color whole-mount in situ hybridization was carried out on chick brain with digoxigenin- and ﬂuorescein-labeled riboprobes synthesized from chick cDNA plasmids for TH

Stage

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Location (click to highlight)

Comments (click to highlight)

25-26

stage 26

Midbrain

Double label
Paper indicates that this is more specifically the oculomotor complex

Entry 5

GEISHA Id	TH.López-Sánchez.2010	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	López-Sánchez C, Bártulos O, Martínez-Campos E, Gañán C, Valenciano AI, García-Martínez V, De Pablo F, Hernández-Sánchez C. Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation. Cardiovasc Res. 2010 Oct 1;88(1):111-20. Epub 2010 Jun 3.
Copyright	© The Author 2010.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204805).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-12

stage 8

stage 9

stage 10

stage 11

stage 12

Atria
Heart
Heart Tube
Lateral Plate Mesoderm
Myocardium
Splanchnic Mesoderm

control embryo - DMSO vehicle
control embryo - ethanol vehicle

Entry 6

GEISHA Id	TH.Huber.2008	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	Huber K, Franke A, Brühl B, Krispin S, Ernsberger U, Schober A, von Bohlen und Halbach O, Rohrer H, Kalcheim C, Unsicker K. Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development. Neural Dev. 2008 Oct 22;3:28.
Copyright	© 2008 Huber et al; licensee BioMed Central Ltd. (requested from Dr. Unsicker)
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204805.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

13-18

stage 15

stage 16

stage 17

stage 18

Intermediate Mesoderm

HH stage 15-

19-21

stage 21

Intermediate Mesoderm

Entry 7

GEISHA Id	TH.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show GCACGAGTCGGCACGAGCGGCACGAGTGAAGATGCCAACCCCCAACATCTCCACCTCTGCAGCCAAAGGCTTCCGCAGG GCGGTGTCAGAGCTGGACTCCAAGCAAGCTGAGGCCATCATGTCTCCACGGTTCATTGGTAGACGCCAAAGCCTCATTG AAGATGCCAGGAAGGAACGAGAGGCTGCAGCTGCAGCCACCGATGCTGCAGAGTCCACAGAGACAATTGTTTTTGAGGA GAAGGACGGGAGAGCCATGCTGAACCTGTTCTTCATGCTCAAGGGTGCCAAGACCTCTCCGCTCTCACGAGCGCTTAAG GTGTTTGAGACATTTGAAGCTAAAATCCACCACTTGGAGACAAGACTCAGCCGAAAGCCCCGTGAAGGGACTGCTGAAC TGGAGTATTTTGTGCGCTGTGAGGTGCACAGCTCTGACCTCAATACTTTCATTAGCTCCATCAAGAGGGTAGCAGAAGA TGTGAGGACCACTAAGGAAGACAAATTTCACTGGTTTCCCAGAAAAATATGTGAACTGGACAAGTGTCACCATTTGGTC ACAAAGTTTGACCCTGACTTAGACTTGGATCATCCGGGCTACTCTGACCAGGTATATCGCCAGAGGAGGAAATCAATAG CAGAAATCGCTTTTCACTATAAGCATGGGGACCCAATCCCTCGTGTGGAGTACACAGCAGAGGAGACTGCTACCTGGAA GGAGGTTTACAGCACTCTGAAGAGCCTGTATCCAACCCATGCCTGCAAGGAGTACCTAGAAGCTTTTAATCTACTGGAG AAATTCTGCGGCTACAATGAGAACAACATCCCCCAGCTGGAGGAGGTCTCCCGCTTCCTGAAAGAGAGGACTGGCTTCC AGCTCCGGCCTGTGGCTGGCCTGTTGTCTGCACGTGACTTCCTCGCCAGCCTGGCCTTCCGTGTGTTCCAGTGCACACA GTATATCCGCCACGCATCTTCGCCCATGCACTCCCCTGAGCCGGACTGCTGTCATGAGCTACTGGGGCATGTCCCAATG CTGGCTGACAAGACGTTTGCCCAGTTCTCCCAGGACATTGGGCTTGCATCTCTGGGAGCAACTGATGAAGAAATTGAGA AACTGGCAACACTTTACTGGTTTACAGTGGAGTTTGGACTCTGCAGACAGAATGGGATAGTCAAAGCCTATGGGGCAGG GCTCCTGTCTTCCTATGGGGAGCTCATACACTCCTTGTCAGATGAACCAGAGGTACGAGACTTTGATCCTGATGCTGCT GCAGTTCAGCCCTACCAGGACCAGAACTACCAGCCTGTGTATTTTGTGTCTGAGAGCTTCAGTGATGCCAAAAACAAGC TGAGGAACTACGCAGCACATATCAAGAGGCCCTTCTCAGTGAAATACGAGCCCTACACCCACAGCATCGAGCTCCTGGA CAGCCCCCAGACCATCTGCCACTCCCTGGAGAGTGTAAGGGACGAGCTTCATTCGCTGATTAACGCGCTCAATGTGATC AGTTAATAAGAGAACTGGGCTCTTCCATTCCCCCCTGCCCTCCCCTGTTCCTAGTCTGTAACTTTTACCTGTTGTCTCC AAACATTTGCACTGCTGCCTGTCCCCACGCTACCCCAACAGTTTACCACATTA
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204805.1).