GEISHA - A Chicken Embryo Gene Expression Database
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CHRNA1
cholinergic receptor nicotinic alpha 1 subunit

The human orthologue of this gene is associated
with the following human diseases:
Gene
Official SymbolCHRNA1
Official Full Namecholinergic receptor nicotinic alpha 1 subunit
CGNC ID7068
also known asNACHRA1, acetylcholine receptor subunit alpha|alpha-1 subunit, nicotinic acetylcholine receptor|cholinergic receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
gene typeprotein-coding
Genomic Map
 Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
Genomic
RNANM_204816
PolypeptideNP_990147
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
EST ProfileGga.7026
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Fruit Fly
Human1134ENSG00000138435MIM:253290MIM:100690
Mouse11435ENSMUSG00000027107All phenotypic alleles (3):Targeted, knock-out(1) Targeted, other(2) MGI:87885
Xenopus394991, 4442965932066
Zebrafish30725ENSDARG00000009021ZDB-GENE-980526-137ZFIN:ZDB-GENE-980526-137
Gene Ontology
Molecular Functionacetylcholine-activated cation-selective channel activity, acetylcholine binding, more...acetylcholine receptor activity
Biological Processmuscle cell cellular homeostasis, neuromuscular junction development, neuromuscular process, more...neuromuscular synaptic transmission, neuronal action potential, neuron cellular homeostasis, skeletal muscle contraction, skeletal muscle tissue growth
Cellular Componentacetylcholine-gated channel complex, cell junction, cell surface, neuromuscular junction, more...postsynaptic membrane
Links to other databases
Entrez Gene395608
Ensembl GeneENSGALG00000009301
KEGGgga:395608

Entry 1

GEISHA IdCHRNA1.UApcrData SourceGEISHA ISH Analysis
Forward cDNA Template Primer5’-AATCCGCATCCCATCAGACG-3’
Reverse cDNA Template Primer5’-AATTAACCCTCACTAAAGGAAGTTGACAGGCACAGGACC-3’cDNA Template Length855
Complete cDNA Template Probeshow
AATCCGCATCCCATCAGACGACATCTGGCGCCCAGATCTTGTCCTTTACAACAATGCAGATGGCGATTTTGCCATTGTT
AAATACACCAAGGTCCTTCTGGAACACACAGGAAAAATCACCTGGACGCCTCCTGCTATCTTTAAAAGTTACTGTGAAA
TTATAGTCACGTACTTCCCATTCGATCAGCAGAACTGTAGCATGAAGCTGGGAACGTGGACGTATGACGGTACAATGGT
GGTTATCAACCCGGAGAGCGATCGCCCCGACCTGAGTAACTTCATGGAGAGCGGTGAGTGGGTGATGAAGGACTACCGT
GGCTGGAAGCACTGGGTTTACTACGCCTGCTGCCCTGACACCCCCTACCTGGACATCACGTACCACTTCCTCATGCAGC
GCCTGCCTCTCTACTTCATCGTCAACGTCATCATCCCCTGCCTGCTCTTCTCCTTTCTGACCGGGTTTGTTTTTTATCT
ACCCACAGATTCAGGTGAGAAAATGACCCTCAGCATCTCTGTCTTGCTGTCACTGACTGTGTTCCTGCTGGTCATCGTG
GAGCTGATTCCCTCTACCTCCAGCGCAGTGCCTCTGATAGGCAAATACATGTTGTTTACCATGGTGTTTGTCATCGCTT
CCATCATCATCACCGTCATCGTCATCAACACCCACCACCGCTCCCCCAGCACTCACACCATGCCACCCTGGGTCAGGAA
GATCTTTATTGACACCATCCCAAACATCATGTTTTTCTCTACGATGAAACGACCATCCAGGGATAAACCAGACAAGAAA
ATTTTTGCAGAAGATATTGATATCTCTGAAATTTCCGGGAAGCAAGGTCCTGTGCCTGTCAACTT
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
4-6
stage 4
stage 5
Epiblast
Primitive Streak
 
7-12
stage 8
stage 9
stage 12
stage 12
Dermomyotome
Extraembryonic Mesoderm
Head Mesenchyme
Intermediate Mesoderm
Lateral Plate Mesoderm
Neural Plate/Tube
Notochord
Sclerotome
extraembryonic mesoderm
 
13-18
stage 17
stage 17
stage 17
Dermomyotome
Foregut
Head Mesenchyme
Leg Mesenchyme
Myotome
Pharyngeal Arches and Clefts
Sinus Venosus
Tail
 
19-24
stage 19
stage 22
stage 23
Aorta
Atria
Dermatome
Foregut
Head Mesenchyme
Leg Mesenchyme
Lung
Myotome
Neural Plate/Tube
Outflow Tract
Pharyngeal Arches and Clefts
Sclerotome
Sinus Venosus
Ventricles
Widespread Expression
Wing Mesenchyme
 
25
stage 25
stage 25
stage 25
stage 25
Dermatome
Foregut
Head Mesenchyme
Leg Mesenchyme
Lung
Mesonephros
Myotome
Pharyngeal Arches and Clefts
Sclerotome
Spinal Cord
Wing Mesenchyme
 

Entry 2

GEISHA IdACHRa.Fontaine.1989Data SourcePublication
Complete cDNA Template Probeshow
CAGGTGATGGAGCTCTGCCGTGTGCTGCTCCTGATCTTCTCCGCAGCCGGGCCGGCCCTGTGCTACGAGCACGAGACGC
GCCTGGTCGATGACCTGTTCCGGGAATACAGCAAGGTGGTGCGCCCCGTGGAGAATCACCGCGATGCCGTCGTCGTCAC
CGTCGGGCTGCAGCTCATTCAGCTCATCAATGTGGATGAAGTAAATCAGATTGTAACAACCAATGTGCGCCTGAAGCAG
CAATGGACAGACATAAACCTGAAGTGGAACCCAGATGACTACGGTGGCGTGAAACAAATCCGCATCCCATCAGACGACA
TCTGGCGCCCAGATCTTGTCCTTTACAACAATGCAGATGGCGATTTTGCCATTGTTAAATACACCAAGGTCCTTCTGGA
ACACACAGGAAAAATCACCTGGACGCCTCCTGCTATCTTTAAAAGTTACTGTGAAATTATAGTCACGTACTTCCCATTC
GATCAGCAGAACTGTAGCATGAAGCTGGGAACGTGGACGTATGACGGTACAATGGTGGTTATCAACCCGGAGAGCGATC
GCCCCGACCTGAGTAACTTCATGGAGAGCGGTGAGTGGGTGATGAAGGACTACCGTGGCTGGAAGCACTGGGTTTACTA
CGCCTGCTGCCCTGACACCCCCTACCTGGACATCACGTACCACTTCCTCATGCAGCGCCTGCCTCTCTACTTCATCGTC
AACGTCATCATCCCCTGCCTGCTCTTCTCCTTTCTGACCGGGTTTGTTTTTTATCTACCCACAGATTCAGGTGAGAAAA
TGACCCTCAGCATCTCTGTCTTGCTGTCACTGACTGTGTTCCTGCTGGTCATCGTGGAGCTGATTCCCTCTACCTCCAG
CGCAGTGCCTCTGATAGGCAAATACATGTTGTTTACCATGGTGTTTGTCATCGCTTCCATCATCATCACCGTCATCGTC
ATCAACACCCACCACCGCTCCCCCAGCACTCACACCATGCCACCCTGGGTCAGGAAGATCTTTATTGACACCATCCCAA
ACATCATGTTTTTCTCTACGATGAAACGACCATCCAGGGATAAACCAGACAAGAAAATTTTTGCAGAAGATATTGATAT
CTCTGAAATTTCCGGGAAGCAAGGTCCTGTGCCTGTCAACTTCTACTCCCCACTTACCAAAAATCCAGATGTGAAAAAC
GCTATAGAGGGAATCAAATACATTGCGGAAACGATGAAGTCAGACCAAGAATCCAGTAATGCGGCTGATGAGTGGAAGT
TTGTTGCGATGGTGCTCGATCATCTTCTCCTCGTAATATTTATGCTAGTCTGCATTATTGGAACATTAGCTGTATTTGC
CGGTCGCCTTATTGAATTAAATCAGCAAGGATGAACATCAAATGGAAACT
CitationFontaine B, Changeux JP. Localization of nicotinic acetylcholine receptor alpha-subunit transcripts during myogenesis and motor endplate development in the chick. J Cell Biol. 1989 Mar;108(3):1025-37.
Copyright© The Rockefeller University Press
CommentsInsufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204816.1)
StageImage (click image to view full size)Location (click to highlight)Comments (click to highlight)
13-18
stage 13
Paraxial Mesoderm
 
19-24
stage 20
stage 24
stage 24
stage 24
stage 24
stage 24
stage 24
Dermomyotome
Leg Muscles
Myotome
Wing Muscles
 
25-30
stage 29
Leg Muscles
 
31-44
stage 34
stage 34
stage 34
stage 37
stage 37
stage 40
stage 41
stage 42
stage 42
stage 42
stage 44
stage 44
stage 44
Leg Muscles
Somatic Mesoderm
20 week old hen, anterior latissimus dorsi
posterior latissimus dorsi
 Data from NCBI Unigene EST Profile
Unigene ID: Gga.7026

Mouse

EmageMGI:87885
EurexpressMGI:87885
MGI GXDMGI:87885

Frog

Xenbase5932066

Fruit Fly

BDGP

Zebra Finch

ZEBrA

Zebrafish

ZFINZDB-GENE-980526-137
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