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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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HOXB8
homeobox B8

Gene

Official Symbol	HOXB8
Official Full Name	homeobox B8
CGNC ID	49449
also known as	CHOX-2.4, Hoxb-8, OX2.4, homeobox protein Hox-B8\|Homeobox protein Hox-2.4\|homeo box B8, Homeobox protein Hox-B8, Chox-2.4
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC

Sequence Information

Genomic
RNA	NM_204911
Polypeptide	NP_990242

Gene Expression

In Situ Hybridization

GEISHA

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	3218	ENSG00000120068		MIM:142963
Mouse	15416	ENSMUSG00000056648	All phenotypic alleles (10):Targeted, knock-out(3) Targeted, other(7)	MGI:96189
Xenopus	100493882			990960
Zebrafish	30420, 30343	ENSDARG00000054025, ENSDARG00000056027	ZDB-GENE-980526-291, ZDB-GENE-990415-108	ZFIN:ZDB-GENE-980526-291, ZFIN:ZDB-GENE-990415-108

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395737
Ensembl Gene
KEGG	gga:395737

Entry 1

GEISHA Id	HOXB8.UApcr	Data Source	GEISHA ISH Analysis
Forward cDNA Template Primer	CCGACCCAAATCCAGGAGTTCTAC
Reverse cDNA Template Primer	TACCACCCGTGCCTGGATACATGAGGTCTTGTCCGCCTTCTGTGCTTC	cDNA Template Length	571
Forward cDNA Template Probe	show CTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCCTCACTCTCCAGCTCCCCTTACCAACAGAATCCC TGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACGACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCC AGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAGCGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCA GAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCCGCTGGACGGAGGAGGGGGAGGCAAACCTACAGC CGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCTACCTGACCCGCAAACGGAGGATCGAGGTCTCGC ATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAACAGGAGGATGAAATGGAAAAAGGAAAACAACAA AGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAACAGAAAATGGAAAGAGCCCAGGAGGTGGACGAG GAAGGGGAAGCACAGA

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 6

Early Mesoderm
Extraembryonic Mesoderm
Primitive Streak

7-12

stage 7

stage 8

stage 9

stage 12

Blood Vessels
Lateral Plate Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak
Spinal Cord

13-18

stage 13

stage 15

stage 17

Blood Vessels
Extraembryonic
Lateral Plate Mesoderm
Paraxial Mesoderm
Primitive Streak
Spinal Cord
Tail

19-24

stage 21

stage 22

stage 23

Lung
Somatic Mesoderm
Spinal Cord
Spinal Ganglia and Nerves
Tail

stage 25

Midgut
Spinal Cord
Spinal Ganglia and Nerves
Tail

Entry 2

GEISHA Id	HOXB8.Sakiyama.2000	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Sakiyama J, Yokouchi Y, Kuroiwa A. Coordinated expression of Hoxb genes and signaling molecules during development of the chick respiratory tract. Dev Biol. 2000 Nov 1;227(1):12-27.
Copyright	Reprinted with permission from Elsevier. Copyright © 2000 Elsevier B.V. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204911).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 24

Lung

25-30

stage 27

stage 29

Lung

31-34

stage 34

Lung

Abdominal Air Sacs (5)
Caudal Thoracic Air Sacs (4)
Cranial Thoracic Air Sacs (3)
Figure 2 compares expression of the Hoxb genes in the developing chick respiratory tract at HH stages 24, 27, 29 and 34.

Entry 3

GEISHA Id	HOXB8.Hughes.2011	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Hughes MW, Wu P, Jiang TX, Lin SJ, Dong CY, Li A, Hsieh FJ, Widelitz RB, Chuong CM. In search of the Golden Fleece: unraveling principles of morphogenesis by studying the integrative biology of skin appendages Integr Biol (Camb). 2011 Apr;3(4):388-407. Epub 2011 Mar 24.
Copyright	© Royal Society of Chemistry 2011
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

25-29

stage 26

stage 29

Dermis

epithelium

Entry 4

GEISHA Id	HOXB8.Huber.2012	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Huber L, Ferdin M, Holzmann J, Stubbusch J, Rohrer H. HoxB8 in noradrenergic specification and differentiation of the autonomic nervous system. Dev Biol. 2012 Mar 1;363(1):219-33. Epub 2011 Dec 24.
Copyright	Copyright © 2011 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

19-24

stage 24

Spinal Cord
Spinal Ganglia and Nerves

25-30

stage 27

stage 29

Spinal Cord
Spinal Ganglia and Nerves
Unlabeled

stage 31

Spinal Cord
Spinal Ganglia and Nerves
Unlabeled

Entry 5

GEISHA Id	HOXB8.Barak.2012	Data Source	Publication
Complete cDNA Template Probe	show TCGGCACAAGTTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCT TCTCCAAATACAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACC CACGGTGGTGTACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCC TCACTCTCCAGCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACG ACCCTTTGCAAAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAG CGGCCTTGGAGAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCC GCTGGACGGAGGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCT ACCTGACCCGCAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAA CAGGAGGATGAAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAA CAGAAAATGGAAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGA GGACTGAAAGGAGAGCGCTGCTGGGGTAGAGAGCCCCCCTCCCCCCTTTTTCTTT
Citation	Barak H, Preger-Ben Noon E, Reshef R. Comparative spatiotemporal analysis of Hox gene expression in early stages of intermediate mesoderm formation. Dev Dyn. 2012 Oct;241(10):1637-49.
Copyright	Copyright © 2012 Wiley Periodicals, Inc.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #NM_204911.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 6

Hensen's Node
Lateral Plate Mesoderm
Neural Plate/Tube
Primitive Streak

7-11

stage 7

stage 8

stage 9

stage 10

stage 11

Central Nervous System
Lateral Plate Mesoderm
Neural Plate/Tube
Paraxial Mesoderm
Primitive Streak

Entry 6

GEISHA Id	Hoxb8.Bel-Vialar.2002	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show TTTTCCTCCTCCTCCGTACAAATATTATTATTTAAATTAAGATGAGCTCCTATTTTGTCAACTCACTCTTCTCCAAATA CAAAACCGGGGACTCGTTGCGTCCCAATTACTATGACTGCGGGTTCGCTCAGGATCTTGGGGGCAGACCCACGGTGGTG TACGGACCCAGCACGGGGGGCACCTTCCAGCATCCGACCCAAATCCAGGAGTTCTACCACGGAGCATCCTCACTCTCCA GCTCCCCTTACCAACAGAATCCCTGCGCCGTGGCGTGCCATGGGGACCCGAGCAACTTCTATGGCTACGACCCTTTGCA AAGGCAGAGCCTCTTCAGCGCCCAGGAGTCGGACTTGGTGCAGTACACGGACTGCAAGCTTGCTGCCAGCGGCCTTGGA GAGGAGGCGGAGAGCTCGGAGCAGAGCCCTTCTCCGACCCAGCTTTTCCCCTGGATGCGACCGCAAGCCGCTGGACGGA GGAGGGGGAGGCAAACCTACAGCCGCTACCAGACGCTGGAACTGGAGAAGGAATTTCTATTTAATCCCTACCTGACCCG CAAACGGAGGATCGAGGTCTCGCATGCCCTGGGATTGACAGAAAGGCAGGTCAAAATCTGGTTCCAGAACAGGAGGATG AAATGGAAAAAGGAAAACAACAAAGACAAGTTTCCCAGCAGCAAATGCGAGCAGGAAGAACTGGAAAAACAGAAAATGG AAAGAGCCCAGGAGGTGGACGAGGAAGGGGAAGCACAGAAGGCGGACAAGAAATAAAAAGGAGTTTTGAGGACTGAAAG GAGAGCGCTGCTGGGGTAGAGAGCCCCC
Citation	Sophie Bel-Vialar, Nobue Itasaki, Robb Krumlauf. Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 2002 Nov;129(22):5103-15.
Copyright	Copyright © The Company of Biologists Limited 2002.
Comments	Authors indicated the probe was a gift from K. Olberg. As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence above was obtained from NCBI (accession number NM_204911.2).