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Human Disease Gene Search
PTCH1 The human orthologue of this gene is associated
Gene Summary Expression Transcript Levels Other Species Expression JBrowse Gene Official Symbol PTCH1 Official Full Name patched 1 CGNC ID 49488 also known as PTC, PTC1, PTCH, protein patched homolog 1|patched homolog 1|patched protein|patched-like protein, patched homolog 1 (PTC1) , PTC gene type protein-coding
Genomic Map Sequence Information Gene Expression Orthology Gene Ontology Links to other databases
Entry 1 GEISHA Id PTCH1.UAlinear Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Comments Insufficient information provided to verify exact sequence used to synthesize probe. Sequence above was obtained from NCBI (NM_204960).
Entry 2 GEISHA Id PTC1.Aglyamova.2007 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Aglyamova GV, Agarwala S. Gene expression analysis of the hedgehog signaling cascade in the chick midbrain and spinal cord. Dev Dyn. 2007 May;236(5):1363-73 Copyright Copyright © 2007 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204960).
Entry 3 GEISHA Id PTC1.Pearse.2001 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Pearse RV, Vogan KJ, Tabin CJ. Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol. 2001 Nov 1;239(1):15-29. Copyright Reprinted with permission from Elsevier.
Copyright © 2001 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204960).
Entry 4 GEISHA Id PTC1.Agarwala.2005 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Agarwala S, Aglyamova GV, Marma AK, Fallon JF, Ragsdale CW. Differential susceptibility of midbrain and spinal cord patterning to floor plate defects in the talpid2 mutant. Dev Biol. 2005 Dec 1;288(1):206-20. Epub 2005 Oct 21. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204960).
Entry 5 GEISHA Id Ptc1.Scherz.2007 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Scherz PJ, McGlinn E, Nissim S, Tabin CJ. Extended exposure to Sonic hedgehog is required for patterning the posterior digits of the vertebrate limb.Dev Biol. 2007 Aug 15;308(2):343-54. Epub 2007 May 31. Copyright Reprinted with permission from Elsevier.
Copyright 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204960.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 21
stage 24
stage 24
Leg
Entry 6 GEISHA Id Ptch1.Liu.2007 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Liu G, Moro A, Zhang JJ, Cheng W, Qiu W, Kim PC. The role of Shh transcription activator Gli2 in chick cloacal development. Dev Biol. 2007 Mar 15;303(2):448-60. Epub 2006 Dec 15 Copyright Reprinted with permission from Elsevier.
Copyright © 2007 Elsevier B.V. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204960.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-18 stage 18
Hindgut 19-24 stage 22
stage 22
Hindgut 25-30 stage 26
stage 26
stage 28
stage 28
stage 30
stage 30
Hindgut
Entry 7 GEISHA Id PTC1.Zhang.2001 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Zhang XM, Yang XJ (2001). Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol. 2001 May 15;233(2):271-90. Copyright Copyright © 2001 Academic Press. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204960).
Entry 8 GEISHA Id PTC.McKinnell.2004 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation McKinnell IW, Turmaine M, Patel K (2004). Sonic Hedgehog functions by localizing the region of proliferation in early developing feather buds. Dev Biol. 2004 Aug 1;272(1):76-88. Copyright Copyright © 2004 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_204960).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 30
stage 30
Feathers/Scutae 31-33 stage 31
stage 31
stage 33
Feathers/Scutae
Entry 9 GEISHA Id PTC.BREN-MATTISON.2002 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Yvette Bren-Mattison and Bradley B. Olwin. Sonic Hedgehog Inhibits the Terminal Differentiation of Limb Myoblasts Committed to the Slow Muscle Lineage. Dev Biol. 2002 Feb 15;242(2):130-48. Copyright Copyright © 2002 Elsevier Science (USA). All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained form NCBI (NM_204960).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 24
stage 24
Leg Mesenchyme
Entry 10 GEISHA Id PTCH1.Moran.2011 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Moran CM, Salanga MC, Krieg PA. Hedgehog signaling regulates size of the dorsal aortae and density of the plexus during avian vascular development. Dev Dyn. 2011 Jun;240(6):1354-64.
Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204960).
Entry 11 GEISHA Id PTCH1.Domowicz.2009 Data Source Publication Complete cDNA Template Probe show ANCNTNATNNCATNTACTNCTNTTNCATANNCACCNCGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAG
Citation Domowicz MS, Cortes M, Henry JG, Schwartz NB. Aggrecan modulation of growth plate morphogenesis. Dev Biol. 2009 May 15;329(2):242-57. Epub 2009 Mar 3. Copyright Copyright © 2009 Published by Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204960.1)
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25-30 stage 29
stage 29
Leg Bones 31-38 stage 38
stage 38
Leg Bones
Entry 12 GEISHA Id PTC1.Dunn.2011 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Dunn IC, Paton IR, Clelland AK, Sebastian S, Johnson EJ, McTeir L, Windsor D, Sherman A, Sang H, Burt DW, Tickle C, Davey MG. The chicken polydactyly (Po) locus causes allelic imbalance and ectopic expression of Shh during limb development. Dev Dyn. 2011 May;240(5):1163-72. Copyright Copyright © 2011 Wiley-Liss, Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204960).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-24 stage 20
Leg Spinal Cord 25-27 stage 27
stage 27
Limb Buds
Entry 13 GEISHA Id PTC1.Grevellec.2011 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Grevellec A, Graham A, Tucker AS. Shh signalling restricts the expression of Gcm2 and controls the position of the developing parathyroids. Dev Biol. 2011 May 15;353(2):194-205. Epub 2011 Feb 22. Copyright Copyright © 2011 Elsevier Inc. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (acc # NM_204960.1).
Entry 14 GEISHA Id PTC1.Ohyama.2008 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Ohyama K, Das R, Placzek M. Temporal progression of hypothalamic patterning by a dual action of BMP. Development. 2008 Oct;135(20):3325-31. Epub 2008 Sep 11. Copyright requested from MP Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. The sequence below was obtained from NCBI (acc # NM_204960.1)
Entry 15 GEISHA Id PTCH1.Moran.2012 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Moran CM, Myers CT, Lewis CM, Krieg PA. Hedgehog regulates angiogenesis of intersegmental vessels through the VEGF signaling pathway. Dev Dyn. 2012 Jun;241(6):1034-42. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204960.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-10 stage 10
stage 10
Neural Plate/Tube Somites
Entry 16 GEISHA Id PTCH1.Wade.2012 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Wade C, Brinas I, Welfare M, Wicking C, Farlie PG.
Twist2 contributes to termination of limb bud outgrowth and patterning through direct regulation of Grem1. Dev Biol. 2012 Oct 1;370(1):145-53.
Copyright Copyright © 2012 Elsevier Inc. All rights reserved Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (Acc. # NM_204960.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 25 stage 25
stage 25
Leg
Entry 17 GEISHA Id PATCHED.Manning.2007 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Manning L, Ohyama K, Saeger B, Hatano O, Wilson SA, Logan M, Placzek M. Regional morphogenesis in the hypothalamus: a BMP-Tbx2 pathway coordinates fate and proliferation through Shh downregulation. Dev Cell. 2006 Dec;11(6):873-85. Copyright Copyright © 2006 Elsevier Inc. All rights reserved. Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_204960.1
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 7-12 stage 11
Hypothalamus 13 stage 13
stage 13
Hypothalamus
Entry 18 GEISHA Id PTC.Marcucio.2005 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Marcucio RS, Cordero DR, Hu D, Helms JA. Molecular interactions coordinating the development of the forebrain and face. Dev Biol. 2005 Aug 1;284(1):48-61. Copyright Copyright © 2005 Elsevier Inc. All rights reserved. Comments Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence was obtained from NCBI (NM_204960.2). Also known as: PTC1; PTCH
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 19-22 stage 20
stage 22
Diencephalon Forebrain all
Entry 19 GEISHA Id Ptc1.Abzhanov.2007 Data Source Publication Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Citation Abzhanov, A., Cordero, D. R., Sen, J., Tabin, C. J. and Helms, J. A. Cross–regulatory interactions between Fgf8 and Shh in the avian frontonasal prominence. Congenit Anom (Kyoto). 2007 Dec;47(4):136-48. Copyright Copyright © 2007 The Authors, Journal compilation © 2007 Japanese Teratology Society Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc # NM_204960.2).
Entry 20 GEISHA Id PTC.Kahane.2013 Data Source GEISHA ISH Analysis Complete cDNA Template Probe show CGCACCGGCGGCGGCAACATGGCCTCGGCCGCTGACGCCTTAGAGCCGGAGAGCGGCAGCAGCACCGCGGGCGGCGGCA
Comments As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence was obtained from NCBI (acc # NM_001305245.1).
Stage Image (click image to view full size) Location (click to highlight) Comments (click to highlight) 13-17 stage 17
Myotome all
Data from NCBI Unigene EST ProfileGga.474
Mouse Frog Fruit Fly Zebra Finch Zebrafish
