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A chicken embryo gene expression database

	Anatomical Location
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	Gene Name
	GEISHA ID
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IGF1R
insulin like growth factor 1 receptor

The human orthologue of this gene is associated
with the following human disease:

Insulin-like growth factor I, resistance to

Gene

Official Symbol	IGF1R
Official Full Name	insulin like growth factor 1 receptor
CGNC ID	49533
also known as	IGF-1R, insulin-like growth factor 1 receptor\|IGF-I receptor\|insulin-like growth factor I receptor\|insulin-like growth factor receptor tyrosine kinase\|type 1 IGF receptor\|tyrosine kinase, IGFR1, insulin-like growth factor 1 receptor
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_205032
Polypeptide	NP_990363
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.2182

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly	42549			FBgn0013984
Human	3480	ENSG00000140443	MIM:270450	MIM:147370
Mouse	16001		All phenotypic alleles (11):Chemically induced(1) Targeted, knock-out(4) Targeted, other(6)	MGI:96433
Xenopus	100329112, 398022			484031
Zebrafish	245702, 245701	ENSDARG00000034434, ENSDARG00000027423	ZDB-GENE-020503-2, ZDB-GENE-020503-1	ZFIN:ZDB-GENE-020503-2, ZFIN:ZDB-GENE-020503-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Links to other databases

Entrez Gene	395889
Ensembl Gene	ENSGALG00000007039
KEGG	gga:395889

Entry 1

GEISHA Id	IGFR1.McCabe.2007	Data Source	Publication
Complete cDNA Template Probe	show `TGCAAGCATGCGTGAGAGGATAGAGTTCTTAAATGAGGCCTCGGTGATGAAGGAGTTCAATTGTCACCACGTGGTTCGC CTGCTAGGTGTTGTTTCTCAGGGCCAGCCTACCCTAGTTATCATGGAGCTGATGACACGTGGGGACCTCAAAAGTTACC TGAGATCATTGAGGCCAGACACAGAGAGTAATCCTGGCC`
Citation	McCabe KL, Shiau CE, Bronner-Fraser M. Identification of candidate secreted factors involved in trigeminal placode induction. Dev Dyn. 2007 Oct;236(10):2925-35.
Copyright	Copyright © 2007 Wiley-Liss, Inc.
Comments	Sequence below was obtained from NCBI (NM_205032) using the primers provided in the publication: IGFR1 forward primer, 5'-TGCAAGCATGCGTGAGAGGATAGA-3'; and reverse primer, 5'-GGCCAGGATTACTCTCTGTGTCTG-3'.

Stage

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Location (click to highlight)

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7-10

stage 8

stage 10

Neural Plate/Tube

Presumptive Trigeminal Placode, Neural Folds
Trigeminal Placode

Entry 2

GEISHA Id	Igf1r.Chapman.2008	Data Source	Direct Submission
Complete cDNA Template Probe	show CGCTTCTCGGCCCTCCGTCGTTGTTATCTGTAGGGCAGAAGAGGACAGCGAACCGTTCGGGACTCGGTTGTTCTTTTCC TTTTTTTTTTTTTTTCCTTTTTTTTTTTTCCGGAAAAGGGGATTTTTTCCGACTAAAGAAAGAGGAATGAAGTCTGGCG CTGGAGGAGGGACCCTCGCCGTCTTCTGCGGGTTGCTGCTCGCCTTCGCCGCGCTCTGCCTGTGTCCGACAAATGGGGA AATTTGTGGGCCAAACGTTGACATTCGCAATGATATCCATGAGCTGAAACGCCTGGAGAACTGTACGGTCGTTGAGGGT TTCCTTCAGATCCTGCTCATCTCTAAAGCAGAGGATTACCGCAACTTCCGCTTCCCGAAACTGACCGTCATAACTGACT ACTTGCTGCTGTTCCGTGTGGCGGGCTTGGAAAGCCTCAGCGATCTCTTCCCCAACCTCACGGTCATTCGCGGGAGGAA CCTCTTCTACAACTATGCCTTGGTGATCTTCGAAATGACAAATCTGAAGGAGATCGGGCTTCACAACTTGAGGAACATA ACCCGCGGGGCCATACGGATTGAGAAGAACTCTGACCTGTGTTACCTCTCCACAGTGGACTGGTCTCTCATCCTAGATG CGGTCTCTAATAACTACATTGTTGGAAATAAGCCTCCGAAGGAGTGCGGGGACTTGTGTCCAGGAACGATGGAGGAGAA GCCGTTGTGCGAGAAGACCTCCATTAACAACGAGTACAACTACCGCTGCTGGACCACCAACCACTGCCAGAAAATGTGC CCCAGCTCATGTGGCAAGAGAGCCTGCACAGACCAGAATGAGTGTTGCCATCCTGAGTGCCTGGGGAGCTGCACAGCAC CCGACAACAACACTGCTTGCGTGGCCTGCCGCAATTACTACTACGAAGGCGTCTGCATGCCCACCTGCCCTCCCAACAC GTACAAGTTTGAGGGCTGGCGCTGTGTGACCAAGGAGTTCTGCTCCAAAGTCCCTGCCACTGAAACAAGTGACTACGAG AGGTTTGTGATTCACAACGATGAGTGCATGGCAGAGTGCCCCTCTGGATTCATACGCAATGGGAGCCAAAGTATGTTCT GCAGTCCTTGTGAGGGGCCTTGCCCCAAAATTTGTGAGGATGGGAAAACGAAGACCATGACTCTGTCACGTCAGCACAA ATGTTGCAGGGATGCACAATTCTCAAGGGAAATTTGCTGATCAACATCCGTCGTGGAAATAACATCGCTTCAGAACTGG AGAATTTCATGGGTCTGATTGAGACAGTGACGGGATATGTGAAGATTCGCCATTCCCATGCATTAGTTTCCCTGTCTTT CTTGAAGAACCTGCGGTATATTCTGGGAGAGGAGCAGGTGGATGGGAATTATTCTTTTTATGTGCTTGATAACCACAAT CTGCAGCAACTGTGGGACTGGAACCATCATAACTTGACGATCAAGGAGGGGAAAATGTACTTTGCATTTAATCCTAAAC TGTGTGTTTCTGAGATCTACCGTATGGAGGAAGTTTCAGGAACCAAAGGGCGACAGAGCAAAGGAGATATAAATCCAAG GAACAATGGGGAGAGAGCCTCTTGTGAAAGCCACATTCTGCGTTTTGTTTCCAACACAACACTGAAGAATCGGATTAAA CTGACGTGGGAGCGGTATCGCCCTCCAGATTACAGAGATCTCATTAGCTTCACTGTTTACTACAAAGAAGCGCCGTTCA AAAATGTGACAGAGTATGATGGACAAGATGCGTGCGGCTCCAATAGCTGGAATATGGTTGATGTTGACTTGCCACCAAA CAAGGAGAATGACCCTGGAATCTTACTGCAGGGATTGAAACCTTGGACTCAGTATGCCATTTATGTCAAGGCTGTTACC CTCACAATGATGGAGAACCATCACATTCATGGAGCAAAAAGTGAAATTGTGTATATACGAACCAATGCTGCAGTACCAT CCATTCCCTTAGATGTTATTTCAGCATCCAACTCCTCTTCCCAATTGATTGTGAAATGGAATCCTCCCTCTCTTCCCAA TGGCAACCTCTCATACTATATTGTACGATGGCAGCAGCAACCTCAGGACAGTTACCTTTACAGACACAATTACTGCTCC AAAGATAAAGTCCCAATTCGAAGATATGCTGATGGTACCATTGATACAGAAGAAGCTACTGAACCCACCAAGCCAGAGG GCTGTGGGGGAGAAAAAGGACCTTGTTGTGCTTGTCCCAAGACAGAGGCAGAAAAACAAGCTGAGAAGGAGGAAGCGGA GTACCGGAAAGTCTTTGAGAACTTCCTTCACAACTCCATCTTTGTCCCCAGACCTGATCGGAAGCGGAGGGATGTGTTC CGAATTGCAAATGCCACTTTGGCCACTCGAAACAGGAACATAACTGGGGCAGATCACTTCACCAATGCTTCTGACGCAG AGGAGAGTGAGGTGGAATACCCGTTCTTTGAGACCAAAGTGGATGGCAAGGAGAGAACTGTGATCTCCCATCTCCAGCC TTTTACTCTTTACCGCATTGATATTCACAGCTGCAACCATGAAGCTGACACGCTTGGTTGCAGCGCTTCCAACTTTGTC TTTGCAAGAACCATGCCTTCAGAGGGAGCAGATAACATTCCAGGAACAGTAGCATGGGAAGCAAAAGAAGAAAATACTG TCTACCTGAAGTGGTTAGAGCCTACAAATCCAAATGGGCTGATACTGATGTATGAAATCAAGTATGGGCAGCATGGGGA GGAGAAACGAGAATGTGTTTCGAGACAGGAGTACAAGAAGCTTGGAGGGGCAAAGCTGACACATCTGAACCCCGGAAAC TATTCTGCTAGAGTTCAGGCCACGTCATTGGCTGGAAATGGATCTTGGACTGAGCCAGTCTCTTTCTATGTACAACCCA AATCAGCAAACTATGACAACTTCCTCCATTTGATAATTGTGCTCCCCATTGCTTTCCTGCTCATCATTGGGGGTTTGCT GATAATGCTGTATGTCTTTAACAAGAAGAGGAACAGTGACAGACTGGGCAATGGAGTACTTTATGCATCTGTGAACCCT GAGTACTTCAGTGCTTCGGATGTGTACGTTCCAGACGAATGGGAGGTGCCCCGCGAGAAGATCACCATGTGCCGTGAGC TTGGGCAGGGCTCTTTTGGGATGGTGTATGAGGGAATAGCCAAGGGAGTGGTGAAGGATGAGCCGGAGACCCGGGTGGC CATCAAAACGTCAATGAGTCTGCAAGCATGCGTGAGAGGATAGAGTTCTTAAATGAGGCCTCGGTGATGAAGGAGTTCA ATTGTCACCACGTGGTTCGCCTGCTAGGTGTTGTTTCTCAGGGCCAGCCTACCCTAGTTATCATGGAGCTGATGACACG TGGGGACCTCAAAAGTTACCTGAGATCATTGAGGCCAGACACAGAGAGTAATCCTGGCCAAGCACCTCCAACTCTGAAG AAGATGATTCAAATGGCAGGAGAGATTGCTGATGGGATGGCATACCTCAACGCCAACAAATTTGTTCACAGAGATCTTG CTGCGAGGAACTGCATGGTGGCAGAAGATTTCACGGTGAAAATCGGAGATTTTGGCATGACAAGAGATATCTACGAGAC AGATTATTACCGGAAAGGAGGGAAAGGTTTGCTGCCCGTCCGCTGGATGTCCCCGGAATCACTGAAGGATGGAGTCTTC ACAACACACTCCGATGTCTGGTCTTTTGGTGTTGTACTTTGGGAGATCGCAACATTAGCAGAGCAGCCGTACCAAGGCA TGACCAATGAGCAAGTGCTCCGCTTTGTGATGGAAGGAGGTCTGCTGGAAAAACCAGACAATTGCCCTGATATGCTGTT TGAACTGATGCGCATGTGCTGGCAGTACAACCCGAAGATGAGGCCGTCCTTCCTGGAAATCATCAGCAGCATTAAGGAC GAGCTGGATCCGGCGTTCAAAGAGGTCTCCTTCTTCTACAGCGAAGAGAACAAGCCTCCGGACACAGAGGAGCTTGACC TGGAGACTGAGAACATGGAGAGCATTCCTTTAGATCCCTCCTCTACCCTCCAACCCACTGACAAGCACTCAGGACACAA AGCCGAGAACGGCCCGGGCGTGGTGGTCCTTCGGGCCAGCTTCGAGGAGAGACAGCCGTACGCACACATGAACGGGGGA CGCAAGAACGAGAGGGCCTTACCGCTGCCCCAGTCTTCGGCCTGCTGATCCTTGGACCCAGAACCTGACAGAAACATAC GCAGAAAAACGCGTGTATTGGGGGAAGAAAGAAAGAAAGTTACAATATGTTCAAAAGCCCTACTGTACCTCAGTGGATC TTCAGAACTGCCATAGCTGCACTTGGGAGAACCCTTTTTTTCAGTAAACAAGTTATCGTTTTTTTTCTTTTTTCAATAT GCAAGCAGATGTTTGTTTCGGTAAAGGACTCCATTCATGGGGCACACAGTTGGCCTTTTAAAACTCTGATGTTAACACT TAATAGCAACAGAAAACTTGAGATTTGATGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT CTCTCCTCTCTCTATCTTTCTTTCTGTCTGTCTTTGCTTCATAATGGGAAACATATCTGCGTGCAAGTTCAACCGTACG GCACTTTTATCAGATCAAAGATATCGCAGGCCAGG
Comments	Images Provided by Susan Chapman

Stage

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4-6

stage 4

stage 5

stage 6

Area Pellucida
Head Process
Hensen's Node
Neural Plate/Tube
Notochord

7-9

stage 8

stage 9

Forebrain
Head Process
Neural Plate/Tube
Notochord

Entry 3

GEISHA Id	IGFR.Camarero.2003	Data Source	Publication
Complete cDNA Template Probe	show CGCTTCTCGGCCCTCCGTCGTTGTTATCTGTAGGGCAGAAGAGGACAGCGAACCGTTCGGGACTCGGTTGTTCTTTTCC TTTTTTTTTTTTTTTCCTTTTTTTTTTTTCCGGAAAAGGGGATTTTTTCCGACTAAAGAAAGAGGAATGAAGTCTGGCG CTGGAGGAGGGACCCTCGCCGTCTTCTGCGGGTTGCTGCTCGCCTTCGCCGCGCTCTGCCTGTGTCCGACAAATGGGGA AATTTGTGGGCCAAACGTTGACATTCGCAATGATATCCATGAGCTGAAACGCCTGGAGAACTGTACGGTCGTTGAGGGT TTCCTTCAGATCCTGCTCATCTCTAAAGCAGAGGATTACCGCAACTTCCGCTTCCCGAAACTGACCGTCATAACTGACT ACTTGCTGCTGTTCCGTGTGGCGGGCTTGGAAAGCCTCAGCGATCTCTTCCCCAACCTCACGGTCATTCGCGGGAGGAA CCTCTTCTACAACTATGCCTTGGTGATCTTCGAAATGACAAATCTGAAGGAGATCGGGCTTCACAACTTGAGGAACATA ACCCGCGGGGCCATACGGATTGAGAAGAACTCTGACCTGTGTTACCTCTCCACAGTGGACTGGTCTCTCATCCTAGATG CGGTCTCTAATAACTACATTGTTGGAAATAAGCCTCCGAAGGAGTGCGGGGACTTGTGTCCAGGAACGATGGAGGAGAA GCCGTTGTGCGAGAAGACCTCCATTAACAACGAGTACAACTACCGCTGCTGGACCACCAACCACTGCCAGAAAATGTGC CCCAGCTCATGTGGCAAGAGAGCCTGCACAGACCAGAATGAGTGTTGCCATCCTGAGTGCCTGGGGAGCTGCACAGCAC CCGACAACAACACTGCTTGCGTGGCCTGCCGCAATTACTACTACGAAGGCGTCTGCATGCCCACCTGCCCTCCCAACAC GTACAAGTTTGAGGGCTGGCGCTGTGTGACCAAGGAGTTCTGCTCCAAAGTCCCTGCCACTGAAACAAGTGACTACGAG AGGTTTGTGATTCACAACGATGAGTGCATGGCAGAGTGCCCCTCTGGATTCATACGCAATGGGAGCCAAAGTATGTTCT GCAGTCCTTGTGAGGGGCCTTGCCCCAAAATTTGTGAGGATGGGAAAACGAAGACCATGACTCTGTCACGTCAGCACAA ATGTTGCAGGGATGCACAATTCTCAAGGGAAATTTGCTGATCAACATCCGTCGTGGAAATAACATCGCTTCAGAACTGG AGAATTTCATGGGTCTGATTGAGACAGTGACGGGATATGTGAAGATTCGCCATTCCCATGCATTAGTTTCCCTGTCTTT CTTGAAGAACCTGCGGTATATTCTGGGAGAGGAGCAGGTGGATGGGAATTATTCTTTTTATGTGCTTGATAACCACAAT CTGCAGCAACTGTGGGACTGGAACCATCATAACTTGACGATCAAGGAGGGGAAAATGTACTTTGCATTTAATCCTAAAC TGTGTGTTTCTGAGATCTACCGTATGGAGGAAGTTTCAGGAACCAAAGGGCGACAGAGCAAAGGAGATATAAATCCAAG GAACAATGGGGAGAGAGCCTCTTGTGAAAGCCACATTCTGCGTTTTGTTTCCAACACAACACTGAAGAATCGGATTAAA CTGACGTGGGAGCGGTATCGCCCTCCAGATTACAGAGATCTCATTAGCTTCACTGTTTACTACAAAGAAGCGCCGTTCA AAAATGTGACAGAGTATGATGGACAAGATGCGTGCGGCTCCAATAGCTGGAATATGGTTGATGTTGACTTGCCACCAAA CAAGGAGAATGACCCTGGAATCTTACTGCAGGGATTGAAACCTTGGACTCAGTATGCCATTTATGTCAAGGCTGTTACC CTCACAATGATGGAGAACCATCACATTCATGGAGCAAAAAGTGAAATTGTGTATATACGAACCAATGCTGCAGTACCAT CCATTCCCTTAGATGTTATTTCAGCATCCAACTCCTCTTCCCAATTGATTGTGAAATGGAATCCTCCCTCTCTTCCCAA TGGCAACCTCTCATACTATATTGTACGATGGCAGCAGCAACCTCAGGACAGTTACCTTTACAGACACAATTACTGCTCC AAAGATAAAGTCCCAATTCGAAGATATGCTGATGGTACCATTGATACAGAAGAAGCTACTGAACCCACCAAGCCAGAGG GCTGTGGGGGAGAAAAAGGACCTTGTTGTGCTTGTCCCAAGACAGAGGCAGAAAAACAAGCTGAGAAGGAGGAAGCGGA GTACCGGAAAGTCTTTGAGAACTTCCTTCACAACTCCATCTTTGTCCCCAGACCTGATCGGAAGCGGAGGGATGTGTTC CGAATTGCAAATGCCACTTTGGCCACTCGAAACAGGAACATAACTGGGGCAGATCACTTCACCAATGCTTCTGACGCAG AGGAGAGTGAGGTGGAATACCCGTTCTTTGAGACCAAAGTGGATGGCAAGGAGAGAACTGTGATCTCCCATCTCCAGCC TTTTACTCTTTACCGCATTGATATTCACAGCTGCAACCATGAAGCTGACACGCTTGGTTGCAGCGCTTCCAACTTTGTC TTTGCAAGAACCATGCCTTCAGAGGGAGCAGATAACATTCCAGGAACAGTAGCATGGGAAGCAAAAGAAGAAAATACTG TCTACCTGAAGTGGTTAGAGCCTACAAATCCAAATGGGCTGATACTGATGTATGAAATCAAGTATGGGCAGCATGGGGA GGAGAAACGAGAATGTGTTTCGAGACAGGAGTACAAGAAGCTTGGAGGGGCAAAGCTGACACATCTGAACCCCGGAAAC TATTCTGCTAGAGTTCAGGCCACGTCATTGGCTGGAAATGGATCTTGGACTGAGCCAGTCTCTTTCTATGTACAACCCA AATCAGCAAACTATGACAACTTCCTCCATTTGATAATTGTGCTCCCCATTGCTTTCCTGCTCATCATTGGGGGTTTGCT GATAATGCTGTATGTCTTTAACAAGAAGAGGAACAGTGACAGACTGGGCAATGGAGTACTTTATGCATCTGTGAACCCT GAGTACTTCAGTGCTTCGGATGTGTACGTTCCAGACGAATGGGAGGTGCCCCGCGAGAAGATCACCATGTGCCGTGAGC TTGGGCAGGGCTCTTTTGGGATGGTGTATGAGGGAATAGCCAAGGGAGTGGTGAAGGATGAGCCGGAGACCCGGGTGGC CATCAAAACGTCAATGAGTCTGCAAGCATGCGTGAGAGGATAGAGTTCTTAAATGAGGCCTCGGTGATGAAGGAGTTCA ATTGTCACCACGTGGTTCGCCTGCTAGGTGTTGTTTCTCAGGGCCAGCCTACCCTAGTTATCATGGAGCTGATGACACG TGGGGACCTCAAAAGTTACCTGAGATCATTGAGGCCAGACACAGAGAGTAATCCTGGCCAAGCACCTCCAACTCTGAAG AAGATGATTCAAATGGCAGGAGAGATTGCTGATGGGATGGCATACCTCAACGCCAACAAATTTGTTCACAGAGATCTTG CTGCGAGGAACTGCATGGTGGCAGAAGATTTCACGGTGAAAATCGGAGATTTTGGCATGACAAGAGATATCTACGAGAC AGATTATTACCGGAAAGGAGGGAAAGGTTTGCTGCCCGTCCGCTGGATGTCCCCGGAATCACTGAAGGATGGAGTCTTC ACAACACACTCCGATGTCTGGTCTTTTGGTGTTGTACTTTGGGAGATCGCAACATTAGCAGAGCAGCCGTACCAAGGCA TGACCAATGAGCAAGTGCTCCGCTTTGTGATGGAAGGAGGTCTGCTGGAAAAACCAGACAATTGCCCTGATATGCTGTT TGAACTGATGCGCATGTGCTGGCAGTACAACCCGAAGATGAGGCCGTCCTTCCTGGAAATCATCAGCAGCATTAAGGAC GAGCTGGATCCGGCGTTCAAAGAGGTCTCCTTCTTCTACAGCGAAGAGAACAAGCCTCCGGACACAGAGGAGCTTGACC TGGAGACTGAGAACATGGAGAGCATTCCTTTAGATCCCTCCTCTACCCTCCAACCCACTGACAAGCACTCAGGACACAA AGCCGAGAACGGCCCGGGCGTGGTGGTCCTTCGGGCCAGCTTCGAGGAGAGACAGCCGTACGCACACATGAACGGGGGA CGCAAGAACGAGAGGGCCTTACCGCTGCCCCAGTCTTCGGCCTGCTGATCCTTGGACCCAGAACCTGACAGAAACATAC GCAGAAAAACGCGTGTATTGGGGGAAGAAAGAAAGAAAGTTACAATATGTTCAAAAGCCCTACTGTACCTCAGTGGATC TTCAGAACTGCCATAGCTGCACTTGGGAGAACCCTTTTTTTCAGTAAACAAGTTATCGTTTTTTTTCTTTTTTCAATAT GCAAGCAGATGTTTGTTTCGGTAAAGGACTCCATTCATGGGGCACACAGTTGGCCTTTTAAAACTCTGATGTTAACACT TAATAGCAACAGAAAACTTGAGATTTGATGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT CTCTCCTCTCTCTATCTTTCTTTCTGTCTGTCTTTGCTTCATAATGGGAAACATATCTGCGTGCAAGTTCAACCGTACG GCACTTTTATCAGATCAAAGATATCGCAGGCCAGG
Citation	Camarero G, Leon Y, Gorospe I, De Pablo F, Alsina B, Giraldez F, Varela-Nieto I. Insulin-like growth factor 1 is required for survival of transit-amplifying neuroblasts and differentiation of otic neurons. Dev Biol. 2003 Oct 15;262(2):242-53.
Copyright	Copyright © 2003 Elsevier Inc. All rights reserved.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205032).

Stage

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Location (click to highlight)

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13-16

stage 16

Ear/Otic Placcode

Entry 4

GEISHA Id	IGF1R.Aburto.2012	Data Source	Publication
Complete cDNA Template Probe	show TTGCCATCCTGAGTGCCTGGGGAGCTGCACAGCACCCGACAACAACACTGCTTGCGTGGCCTGCCGCAATTACTACTAC GAAGGCGTCTGCATGCCCACCTGCCCTCCCAACACGTACAAGTTTGAGGGCTGGCGCTGTGTGACCAAGGAGTTCTGCT CCAAAGTCCCTGCCACTGAAACAAGTGACTACGAGAGGTTTGTGATTCACAACGATGAGTGCATGGCAGAGTGCCCCTC TGGATTCATACGCAATGGGAGCCAAAGTATGTTCTGCAGTCCTTGTGAGGGGCCTTGCCCCAAAATTTGTGAGGATGGG AAAACGAAGACCATGACTCTGTCACGTCAGCACAAATGTTGCAGGGATGCACAATTCTCAAGGGAAATTTGCTGATCAA CATCCGTCGTGGAAATAACATCGCTTCAGAACTGGAGAATTTCATGGGTCTGATTGAGACAGTGACGGGATATGTGAAG ATTCGCCATTCCCATGCATTAGTTTCCCTGTCTTTCTTGAAGAACCTGCGGTATATTCTGGGAGAGGAGCAGGTGGATG GGAATTATTCTTTTTATGTGCTTGATAACCACAATCTGCAGCAACTGTGGGACTGGAACCATCATAACTTGACGATCAA GGAGGGGAAAATGTACTTTGCATTTAATCCTAAACTGTGTGTTTCTGAGATCTACCGTATGGAGGAAGTTTCAGGAACC AAAGGGCGACAGAGCAAAGGAGATATAAATCCAAGGAACAATGGGGAGAGAGCCTCTTGTGAAAGCCACATTCTGCGTT TTGTTTCCAACACAACACTGAAGAATCGGATTAAACTGACGTGGGAGCGGTATCGCCCTCCAGATTACAGAGATCTCAT TAGCTTCACTGTTTACTACAAAGAAGCGCCGTTCAAAAATGTGACAGAGTATGATGGACAAGATGCGTGCGGCTCCAAT AGCTGGAATATGGTTGATGTTGACTTGCCACCAAACAAGGAGAATGACCCTGGAATCTTACTGCAGGGATTGAAACCTT GGACTCAGTATGCCATTTATGTCAAGGCTGTTACCCTCACAATGATGGAGAACCATCACATTCATGGAGCAAAAAGTGA AATTGTGTATATACGAACCAATGCTGCAGTACCATCCATTCCCTTAGATGTTATTTCAGCATCCAACTCCTCTTCC
Citation	Aburto MR, Magariños M, Leon Y, Varela-Nieto I, Sanchez-Calderon H. AKT signaling mediates IGF-I survival actions on otic neural progenitors. PLoS One. 2012;7(1):e30790.
Copyright	Copyright: © 2012 Aburto et al.
Comments	The cDNA template used to generate the probe was obtained by PCR using the information provided in the publication.

Stage

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Comments (click to highlight)

stage 19

Ear/Otic Placode

IGF1R in situ (purple)
ISLET-1 immunohistochemistry (red)
double-labeled:

Entry 5

GEISHA Id	IGF-1R.Holzenberger.1996	Data Source	Publication
Complete cDNA Template Probe	show CGCTTCTCGGCCCTCCGTCGTTGTTATCTGTAGGGCAGAAGAGGACAGCGAACCGTTCGGGACTCGGTTGTTCTTTTCC TTTTTTTTTTTTTTTCCTTTTTTTTTTTTCCGGAAAAGGGGATTTTTTCCGACTAAAGAAAGAGGAATGAAGTCTGGCG CTGGAGGAGGGACCCTCGCCGTCTTCTGCGGGTTGCTGCTCGCCTTCGCCGCGCTCTGCCTGTGTCCGACAAATGGGGA AATTTGTGGGCCAAACGTTGACATTCGCAATGATATCCATGAGCTGAAACGCCTGGAGAACTGTACGGTCGTTGAGGGT TTCCTTCAGATCCTGCTCATCTCTAAAGCAGAGGATTACCGCAACTTCCGCTTCCCGAAACTGACCGTCATAACTGACT ACTTGCTGCTGTTCCGTGTGGCGGGCTTGGAAAGCCTCAGCGATCTCTTCCCCAACCTCACGGTCATTCGCGGGAGGAA CCTCTTCTACAACTATGCCTTGGTGATCTTCGAAATGACAAATCTGAAGGAGATCGGGCTTCACAACTTGAGGAACATA ACCCGCGGGGCCATACGGATTGAGAAGAACTCTGACCTGTGTTACCTCTCCACAGTGGACTGGTCTCTCATCCTAGATG CGGTCTCTAATAACTACATTGTTGGAAATAAGCCTCCGAAGGAGTGCGGGGACTTGTGTCCAGGAACGATGGAGGAGAA GCCGTTGTGCGAGAAGACCTCCATTAACAACGAGTACAACTACCGCTGCTGGACCACCAACCACTGCCAGAAAATGTGC CCCAGCTCATGTGGCAAGAGAGCCTGCACAGACCAGAATGAGTGTTGCCATCCTGAGTGCCTGGGGAGCTGCACAGCAC CCGACAACAACACTGCTTGCGTGGCCTGCCGCAATTACTACTACGAAGGCGTCTGCATGCCCACCTGCCCTCCCAACAC GTACAAGTTTGAGGGCTGGCGCTGTGTGACCAAGGAGTTCTGCTCCAAAGTCCCTGCCACTGAAACAAGTGACTACGAG AGGTTTGTGATTCACAACGATGAGTGCATGGCAGAGTGCCCCTCTGGATTCATACGCAATGGGAGCCAAAGTATGTTCT GCAGTCCTTGTGAGGGGCCTTGCCCCAAAATTTGTGAGGATGGGAAAACGAAGACCATGACTCTGTCACGTCAGCACAA ATGTTGCAGGGATGCACAATTCTCAAGGGAAATTTGCTGATCAACATCCGTCGTGGAAATAACATCGCTTCAGAACTGG AGAATTTCATGGGTCTGATTGAGACAGTGACGGGATATGTGAAGATTCGCCATTCCCATGCATTAGTTTCCCTGTCTTT CTTGAAGAACCTGCGGTATATTCTGGGAGAGGAGCAGGTGGATGGGAATTATTCTTTTTATGTGCTTGATAACCACAAT CTGCAGCAACTGTGGGACTGGAACCATCATAACTTGACGATCAAGGAGGGGAAAATGTACTTTGCATTTAATCCTAAAC TGTGTGTTTCTGAGATCTACCGTATGGAGGAAGTTTCAGGAACCAAAGGGCGACAGAGCAAAGGAGATATAAATCCAAG GAACAATGGGGAGAGAGCCTCTTGTGAAAGCCACATTCTGCGTTTTGTTTCCAACACAACACTGAAGAATCGGATTAAA CTGACGTGGGAGCGGTATCGCCCTCCAGATTACAGAGATCTCATTAGCTTCACTGTTTACTACAAAGAAGCGCCGTTCA AAAATGTGACAGAGTATGATGGACAAGATGCGTGCGGCTCCAATAGCTGGAATATGGTTGATGTTGACTTGCCACCAAA CAAGGAGAATGACCCTGGAATCTTACTGCAGGGATTGAAACCTTGGACTCAGTATGCCATTTATGTCAAGGCTGTTACC CTCACAATGATGGAGAACCATCACATTCATGGAGCAAAAAGTGAAATTGTGTATATACGAACCAATGCTGCAGTACCAT CCATTCCCTTAGATGTTATTTCAGCATCCAACTCCTCTTCCCAATTGATTGTGAAATGGAATCCTCCCTCTCTTCCCAA TGGCAACCTCTCATACTATATTGTACGATGGCAGCAGCAACCTCAGGACAGTTACCTTTACAGACACAATTACTGCTCC AAAGATAAAGTCCCAATTCGAAGATATGCTGATGGTACCATTGATACAGAAGAAGCTACTGAACCCACCAAGCCAGAGG GCTGTGGGGGAGAAAAAGGACCTTGTTGTGCTTGTCCCAAGACAGAGGCAGAAAAACAAGCTGAGAAGGAGGAAGCGGA GTACCGGAAAGTCTTTGAGAACTTCCTTCACAACTCCATCTTTGTCCCCAGACCTGATCGGAAGCGGAGGGATGTGTTC CGAATTGCAAATGCCACTTTGGCCACTCGAAACAGGAACATAACTGGGGCAGATCACTTCACCAATGCTTCTGACGCAG AGGAGAGTGAGGTGGAATACCCGTTCTTTGAGACCAAAGTGGATGGCAAGGAGAGAACTGTGATCTCCCATCTCCAGCC TTTTACTCTTTACCGCATTGATATTCACAGCTGCAACCATGAAGCTGACACGCTTGGTTGCAGCGCTTCCAACTTTGTC TTTGCAAGAACCATGCCTTCAGAGGGAGCAGATAACATTCCAGGAACAGTAGCATGGGAAGCAAAAGAAGAAAATACTG TCTACCTGAAGTGGTTAGAGCCTACAAATCCAAATGGGCTGATACTGATGTATGAAATCAAGTATGGGCAGCATGGGGA GGAGAAACGAGAATGTGTTTCGAGACAGGAGTACAAGAAGCTTGGAGGGGCAAAGCTGACACATCTGAACCCCGGAAAC TATTCTGCTAGAGTTCAGGCCACGTCATTGGCTGGAAATGGATCTTGGACTGAGCCAGTCTCTTTCTATGTACAACCCA AATCAGCAAACTATGACAACTTCCTCCATTTGATAATTGTGCTCCCCATTGCTTTCCTGCTCATCATTGGGGGTTTGCT GATAATGCTGTATGTCTTTAACAAGAAGAGGAACAGTGACAGACTGGGCAATGGAGTACTTTATGCATCTGTGAACCCT GAGTACTTCAGTGCTTCGGATGTGTACGTTCCAGACGAATGGGAGGTGCCCCGCGAGAAGATCACCATGTGCCGTGAGC TTGGGCAGGGCTCTTTTGGGATGGTGTATGAGGGAATAGCCAAGGGAGTGGTGAAGGATGAGCCGGAGACCCGGGTGGC CATCAAAACGTCAATGAGTCTGCAAGCATGCGTGAGAGGATAGAGTTCTTAAATGAGGCCTCGGTGATGAAGGAGTTCA ATTGTCACCACGTGGTTCGCCTGCTAGGTGTTGTTTCTCAGGGCCAGCCTACCCTAGTTATCATGGAGCTGATGACACG TGGGGACCTCAAAAGTTACCTGAGATCATTGAGGCCAGACACAGAGAGTAATCCTGGCCAAGCACCTCCAACTCTGAAG AAGATGATTCAAATGGCAGGAGAGATTGCTGATGGGATGGCATACCTCAACGCCAACAAATTTGTTCACAGAGATCTTG CTGCGAGGAACTGCATGGTGGCAGAAGATTTCACGGTGAAAATCGGAGATTTTGGCATGACAAGAGATATCTACGAGAC AGATTATTACCGGAAAGGAGGGAAAGGTTTGCTGCCCGTCCGCTGGATGTCCCCGGAATCACTGAAGGATGGAGTCTTC ACAACACACTCCGATGTCTGGTCTTTTGGTGTTGTACTTTGGGAGATCGCAACATTAGCAGAGCAGCCGTACCAAGGCA TGACCAATGAGCAAGTGCTCCGCTTTGTGATGGAAGGAGGTCTGCTGGAAAAACCAGACAATTGCCCTGATATGCTGTT TGAACTGATGCGCATGTGCTGGCAGTACAACCCGAAGATGAGGCCGTCCTTCCTGGAAATCATCAGCAGCATTAAGGAC GAGCTGGATCCGGCGTTCAAAGAGGTCTCCTTCTTCTACAGCGAAGAGAACAAGCCTCCGGACACAGAGGAGCTTGACC TGGAGACTGAGAACATGGAGAGCATTCCTTTAGATCCCTCCTCTACCCTCCAACCCACTGACAAGCACTCAGGACACAA AGCCGAGAACGGCCCGGGCGTGGTGGTCCTTCGGGCCAGCTTCGAGGAGAGACAGCCGTACGCACACATGAACGGGGGA CGCAAGAACGAGAGGGCCTTACCGCTGCCCCAGTCTTCGGCCTGCTGATCCTTGGACCCAGAACCTGACAGAAACATAC GCAGAAAAACGCGTGTATTGGGGGAAGAAAGAAAGAAAGTTACAATATGTTCAAAAGCCCTACTGTACCTCAGTGGATC TTCAGAACTGCCATAGCTGCACTTGGGAGAACCCTTTTTTTCAGTAAACAAGTTATCGTTTTTTTTCTTTTTTCAATAT GCAAGCAGATGTTTGTTTCGGTAAAGGACTCCATTCATGGGGCACACAGTTGGCCTTTTAAAACTCTGATGTTAACACT TAATAGCAACAGAAAACTTGAGATTTGATGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT CTCTCCTCTCTCTATCTTTCTTTCTGTCTGTCTTTGCTTCATAATGGGAAACATATCTGCGTGCAAGTTCAACCGTACG GCACTTTTATCAGATCAAAGATATCGCAGGCCAGG
Citation	Holzenberger M1, Lapointe F, Leibovici M, Lièvre CA. The avian IGF type 1 receptor: cDNA analysis and in situ hybridization reveal conserved sequence elements and expression patterns relevant for the development of the nervous system. Brain Res Dev Brain Res. 1996 Nov 22;97(1):76-87.
Copyright	Copyright © 1996 Published by Elsevier B.V.
Comments	Insufficient information provided in publication to verify exact sequence used to synthesize probe. Sequence below was obtained from NCBI (NM_205032.1).

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

13-18

stage 14

Ectoderm
Mesencephalon
Neural Plate/Tube
Rhombomeres
Spinal Cord
Telencephalon

19-24

stage 23

Cranial Ganglia
Gut
Limb Buds
Mesencephalon
Neural Plate/Tube
Notochord
Rhombomeres
Spinal Ganglia and Nerves
Telencephalon

floor plate
ventral horns

31-42

stage 42

Hindbrain
Hypothalamus
Nasal Placode/Nerve
Pineal Gland
Retina
Telencephalon

Entry 6

GEISHA Id	IGF-1R.Holzenberger.2000	Data Source	Publication
Complete cDNA Template Probe	show `GCATAGTTGTAGAAGAGGTTCCTCCCGCGACCTTCAGATTTGTCATTTCGAAGATCACCAGGTTATGTTCCTCAAGTTG TGAAGCCCGATGTCAGAGTTCTTCTCAATCCGTATGGCCCCTCCAACAATGTAGGTATTAGAGACCGCATCACAAGTCC CCGCACTCCTTCGGAGGCTTAT`
Citation	Holzenberger M, Lapointe F, Ayer-LeLièvre C. Expression of insulin-like growth factor-I (IGF-I) and IGF-II in the avian brain: relationship of in situ hybridization patterns with IGF type 1 receptor expression. Int J Dev Neurosci. 2000 Feb;18(1):69-82.
Copyright	Copyright © 2000 ISDN. Published by Elsevier Ltd.
Comments	The complete cDNA template sequence was obtained from the information provided in the publication as described in Holzenberger et al. 2000.

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