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A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

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PTN
pleiotrophin

Gene

Official Symbol	PTN
Official Full Name	pleiotrophin
CGNC ID	50678
also known as	HB-GAM, HBBM, HBGF-8, HBNF, OSF-1, pleiotrophin\|heparin-binding brain mitogen\|heparin-binding growth factor 8\|heparin-binding growth-associated molecule\|heparin-binding neutrophic factor\|neurite growth-promoting factor 1\|osteoblast-specific factor 1\|pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
gene type	protein-coding

Genomic Map

	Ensembl ID not known
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001276362
Polypeptide	NP_001263291
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.39450

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	5764	ENSG00000105894		MIM:162095
Mouse	19242	ENSMUSG00000029838	All phenotypic alleles (2):Targeted, knock-out(2)	MGI:97804
Xenopus	100101785, 444715			481633
Zebrafish	368211	ENSDARG00000045798	ZDB-GENE-030624-1	ZFIN:ZDB-GENE-030624-1

Gene Ontology

Molecular Function	growth factor activity, heparin binding
Biological Process	positive regulation of cell division
Cellular Component	extracellular region

Links to other databases

Entrez Gene	418125
Ensembl Gene
KEGG	gga:418125

Entry 1

GEISHA Id	HBGAM.Chambers.2006	Data Source	Publication
Complete cDNA Template Probe	show GGCGCGGGAGGAGTGGGGCGTGAGTCGGAGGTCCGTGGAGAAGCGGAGCCGCGGCGCCGTCAGCACCCGCAGCACCCGC CGCGCACCGGGGACGCCCGCGGCTCGCCCCTTACAGCTGCGGGAGAAGCGCTTCTCGCCGCCCGAAAATGCCACAGCAA CAACAGCAACGTCGAATGTTCACGGCTGCTCTCCTGGCACTTGTCTTCATTCTGGCAGCAGTGAGTACCACTGAGGCTG GAAAGAAAGAGAAACCAGAGAAAAAGGCCAAGAAGTCTGACTGTGGGGAATGGCAGTGGAGTGTCTGTGTGCCCACCAA TGGAGACTGTGGCCTGGGGACACGCGAGGGCACTCGCACTGGAGCAGAGTGCAAACAAACCACCAAGACTCAGAAGTGT AAGATTCCCTGCAACTGGAAGAAGCAATTTGGAGCAGAGTGTAAATACCAATTCCAGGCCNNNNGAGAATGTGACTTGA ATACTGCCTTGAAAACTCGAACNNNNNACCTAAAGAGAGCTCTTCATAATGCTGACTGCCAGAAGACTGTCACAATCTC AAAGCCCTGTGGGAAGCTTACCAAACCCAAACCTCAA
Citation	Chambers, D, Mason, I, A high throughput messenger RNA differential display screen identifies discrete domains of gene expression and novel patterning processes along the developing neural tube. BMC Dev Biol. 2006; 6: 9. Published online 2006 February 24.
Copyright	Copyright © 2006 Chambers and Mason; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #BI394859.1).

Stage

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Location (click to highlight)

Comments (click to highlight)

7-11

stage 10

stage 11

Neural Plate/Tube
Paraxial Mesoderm

Entry 2

GEISHA Id	PTN.Lee.2012	Data Source	Publication
Complete cDNA Template Probe	show CCCAAACCTCAAGAATCCAAGAAGAAGAAAAAGGAAGGCAAGAAACAAGAGAAGATGCTGGATTAATGGAGCCAACTTG GGCAATGTGAGAAAGGGACATCAGCAAACATGATCGGTTAACAGTTTCATTTATACCTAGGCATTTTACCCTAAAATTA TTTATAGCTTAATGGTACAATAGAAGGAAACAAGCAAACACAGACAAAAAATATCCTTTTTTATTTACTTTAGTATTTT TAATGTATAACCCTAACAACAATTTTAGAGGCCTGTCGTAAAGGATTCCAAACTCATTTAGAAAATTCTGTCTATTGCA TATTGAACAGTGTAGAGGTTTTTAAAATATTTTTTTCTCAAGTCTTGCTGTAGGTCTCAGTCTTTTAACTACTCCATGC AAGCAGAATTTGAACCTGTGTAGAGCCCTGCTGAACCCAGTGATAACCCTGTGTGGATGCAGGAGTCTGGTTGGGTGCA GTTATATTTAAAATTAGGACCATATGAGTGAAACAACAAACAAATACTGTTTCTTAAGTTGTTGTTACATCTGGATAAC TGTATGAAGTTATTTGTTTAAGGAGAGGATGGGGGCATTTTGTTGAGCATTTGCAGGCTAGGAATTTTTTTCTGTGTGT GGTGAATGTTCATTCCAAACTGTAATAGTCTGGGTAAAAACAGTAGTGTTCATATCTTGGTTCCTGGCAGTAAAAATAG TAAAATCTTTCAGTGGTTTGATATAGCAGGTTCCTAAACTTTTAGGTTTTTGTAGAAAAGGTATTTTCTACAAAAATAT CTAGGTGGAAAGATAGCAAGACTCTTCTTCTTTACCGTATTGACACTGGTGAATGACAATGTCATCTGTTTTACCTGCA AAAGCACAAACATGCTTTATTTCTTTCTTCCTTTTTAATTTATTTTTTATTTTTTTCCCCAGAATGGAGAATATCTTTT TCATAAAAATCTAATTGAAATTGTTGCTATTCTACCTGACCCAACTCTCTTTTGTATTAGTGAGAATCTTCCTGCAGAT TTTAACTATAACTGGTTGAAAGTAGAAATTATGTATAGTGGGAAGAAACAGAACAAATCAGTTTGGAAACTATCTAAGA TGGCTCGTATTTCTGACCAGAAAAGGGGCACTTTATGAGACTTGAAACAAATAAGAATGAAATTAATTTTTAGTTTCAT TTGTCTATTAGTAAAGCAGAAGGGAAATGTCAAGATGGTACCTTTTGCTTCCTTCCATTTTTAAATAAGTAAAAACACC TTGGAAAATCTTAGCCATAAAGATATATTTTTTTCTTTTAATTTCATTTTTAACTCAAAAAGGAAAAAAATATAAAACC TGTTGTTTTTCTGTTTTTTTTTACATATTTCAAATGATAATGAGTCCTGAGAAAAGTCAGAGTAGAAAAAAGATCTTGC AATGAGTTGGTGTATCCTCAGGTGAAAGATTGTTTTACAAGCCAAACAACGTTCAGACCAGATATATTAGAAGAAACCT ATGGGATTTCAAGTGCTCAAATTCTTTTAAAAACCACCCTTTAAAAATTATAAGTCTTAAATTTCGTAAGCAAGAAGTA ACCTTCACTGTTGGTGTAGGCTCCAGGCTTTGCCTGCTGGTCAACAGGAAGTCTCCCAAAGTCTCCCTTTTGCTCCTGC AGATACTCATTGACTTCAGTGAAACTTCATCAGGGTGCAATCATCTGGGTAAATCACAATGCTCTTTTGGAATTAGCTT ATAGAAATGCAGAGTCTTTTACTGGTCTATCTTCTCACTTCCCTTTTCTAAGCAGAAAATAAAAATTAAAAAAAGCA
Citation	Lee JY, Jeong W, Lim W, Kim J, Bazer FW, Han JY, Song G.. Chicken Pleiotrophin: Regulation of Tissue Specific Expression by Estrogen in the Oviduct and Distinct Expression Pattern in the Ovarian Carcinomas. PLoS One. 2012; 7(4): e34215.
Copyright	Copyright Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Comments	Authors indicated sense primer (5';-TGC TCT CCT GGC ACT TGT CT-3';), antisense primer (5';-CTT GGA TTC TTG AGG TTT GGG-3'). As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI (acc #XM_003640397.1 ).

Stage

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Location (click to highlight)

Comments (click to highlight)

stage 1

Intermediate Mesoderm

Isthmus
Magnum
Shell Gland

Entry 3

GEISHA Id	PTN.Cui.2019	Data Source	Publication
Complete cDNA Template Probe	show ATGCCACAGCAACAACAGCAACGTCGAATGTTCACGGCTGCTCTCCTGGCACTTGTCTTCATTCTGGCAGCAGTGAGTA CCACTGAGGCTGGAAAGAAAGAGAAACCAGAGAAAAAGGCCAAGAAGTCTGACTGTGGGGAATGGCAGTGGAGTGTCTG TGTGCCCACCAATGGAGACTGTGGTCTGGGGACACGTGAGGGCACTCGCACTGGAGCAGAGTGCAAACAAACCACCAAG ACTCAGAAGTGTAAGATTCCCTGCAACTGGAAGAAGCAATTTGGAGCAGAGTGTAAATACCAATTCCAGGCCTGGGGAG AATGTGACTTGAATACTGCCTTGAAAACTCGAACTGGGAACCTAAAGAGAGCTCTTCATAATGCTGACTGCCAGAAGAC TGTCACAATCTCAAAGCCCTGTGGGAAGCTTACCAAACCCAAACCTCAAGAATCCAAGAAGAAGAAAAAGGAAGGCAAG AAACAAGAGAAGATGCTGGATTAA
Citation	Cui R, Lwigale P. Expression of the heparin-binding growth factors Midkine and pleiotrophin during ocular development. Gene Expr Patterns. 2019 Jun;32:28-37. Epub 2019 Feb 27. DOI: 10.1016/j.gep.2019.02.001.
Copyright	Copyright © 2019 Elsevier B.V.
Comments	The complete cDNA template sequence was obtained from the information provided in the publication as described in Cui et al. 2019. PTN is also known in NCBI as: HBBM; HBNF; OSF-1; HB-GAM; HBGF-8.