Geisha

home

contact

A chicken embryo gene expression database

	Anatomical Location
	Stage
	Gene Name
	GEISHA ID
	Multiple Parameters

Quick Search

Data Class

Enter Text:

Gene Family QuickSearch

	Transcription Factors
	Growth Factors
	Receptors
	MicroRNAs

Human Disease Gene Search

	Downloads
	Protocols
	About GEISHA
	Contact Us

	Transgenic Birds
	Model Organism Databases
	Gene Expression Databases
	Genomic Resources
	Anatomical Atlases
	Chicken Stage Series

MYCN
MYCN proto-oncogene, bHLH transcription factor

The human orthologue of this gene is associated
with the following human disease:

Feingold syndrome

Gene

Official Symbol	MYCN
Official Full Name	MYCN proto-oncogene, bHLH transcription factor
CGNC ID	12325
also known as	N-myc proto-oncogene protein\|N-myc protein\|v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog\|v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
gene type	protein-coding

Genomic Map

	Ensembl
	NCBI
	UCSC
	Gallus-Browse

Sequence Information

Genomic
RNA	NM_001031091
Polypeptide	NP_001026262
Sequence Clusters/ESTs	Unigene

Gene Expression

In Situ Hybridization	GEISHA
EST Profile	Gga.5109

Orthology

	Entrez Gene	Ensembl Gene	Genetic Phenotypes	MOD
Fruit Fly
Human	4613	ENSG00000134323	MIM:164280	MIM:164840
Mouse	18109	ENSMUSG00000037169	All phenotypic alleles (12):Targeted, knock-out(7) Targeted, other(5)	MGI:97357
Xenopus	448649, 380041, 100337516			478858
Zebrafish	252851		ZDB-GENE-020711-1	ZFIN:ZDB-GENE-020711-1

Gene Ontology

Molecular Function	DNA binding, protein dimerization activity, sequence-specific DNA binding transcription factor activity
Biological Process
Cellular Component	nucleus

Links to other databases

Entrez Gene	421948
Ensembl Gene	ENSGALG00000016462
KEGG	gga:421948

Entry 1

GEISHA Id	MYCN.Khudyakov.2009	Data Source	Publication
Complete cDNA Template Probe	show GTCTTCCCCTTCCCCGTCAACAAGCGGGAGGCGGCGGTGCCAAGCGGCGGCGAGACCCCGCGGGGCGGCCGCCCGCCGC GTCCCGCGGGGGAGAGCCGGGCCAGCAGCAGCTCCGGGGACGACACGCTCAGCGACTCGGATGATGAAGACGAGGAGGA AGAGGATGATGAAGAAGAAATAGATGTTGTGACAGTGGAGAAAAGACGCTCCTCCTCCAACAAGGCTGTTACCACCCTC ACTATTACAGTGCGTCCTAAAAATACCACTTTTCCATCGGTCAGGACACAGCAGAATGAACTGATTTTAAAGCGTTGTG CGCCAATTCACCAGCAGCATAATTATGCCGCTCCTTCTCCATATATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTT AAAAGCCGAGGTGCCCCGTCCAGTAAAACCCATGATCCAACCAAAGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCG GAGGACAGCGAACGTCGACGTAACCATAATATCTTGGAGCGTCAGAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGT TAAGGGACCACGTTCCAGAACTTGTTAAACAATGAGGAAAGCTGCAAAAGCTGTGATTTTGAAAAAAGCCACTTGAATA TGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTTATTGCTAGAAACAGGAGAAATTGCAAGCCAGGCAACAACAGTTGCT AACAGAACAATAGAGTACAG
Citation	Khudyakov J, Bronner-Fraser M. Comprehensive spatiotemporal analysis of early chick neural crest network genes. Dev Dyn. 2009 Mar;238(3):716-23.
Copyright	Published Online: 22 Feb 2009 Copyright © 2009 Wiley-Liss, Inc.
Comments	The sequence below was obtained from NCBI (BU334398) using the information provided in the publication.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

4-6

stage 4

stage 5

stage 6

Ectoderm
Epiblast
Neural Plate/Tube

neural plate border

7-10

stage 7

stage 8

stage 9

stage 10

Ectoderm
Heart
Lateral Plate Mesoderm
Mesoderm
Neural Crest
Neural Plate/Tube
Somites

Entry 2

GEISHA Id	NMYC.Hu.2012	Data Source	Publication
Complete cDNA Template Probe	show ATGCCGGGAATGATCAGCAAGAACCCGGACCTCGAGTTCGATTCCTTACAGCCTTGTTTCTACCCGGACGAAGATGATT TCTATTTATGCGGGCCGGACTCGGCCCCCCCCGGGGAAGACATCTGGAAGAAGTTCGAGCTGCTGCCCACCCCTCCGCT GTCCCCCAGCCGGGCCGGGCTGCAGGAGCCACCCCCCGGGGGGGGCTCCATTGCCGTGGGGAGGGGCGGACCTGGGGAG TGCCGCCCCGTTGATCCCCTGGACTGGGCGTCCGAGTTGCTCCTCCTGCCCCCCGAGGCCGAGCTGTGGGGCAGCACGG ACGGCGCGGATTTCTTCGAGACGGGCCTCGGGGCGAGCAACAACCTCAACTCCATCATCATCCAGGACTGCATGTGGAG TGCGTTCTCGGCCCGCGAGAAGCTGGAGCGGGCGGTCAGCGAGAAGCTGCAGAGCAAGCCTCCCGCCGCCGCCCCGCCG CCTCCGCCCCCGGTTGTACCCACCGCCGCTTGTCGCCGCCGCGAACAGCCCCAGCGCGGTCCCGGCCGCGCGGAGCTGG GCGGCTCCGTGCCCGAGTGCGTGGACCCGGCCGTGGTCTTCCCCTTCCCCGTCAACAAGCGGGAGGCGGCGGTGCCAAG CGGCGGCGAGACCCCGCGGGGCGGGCGCCGGCCGGGTCCCGCGGGGGAGAGCCGGGCCAGCAGCAGCTCCGGGGACGAC ACGCTCAGCGACTCGGATGATGAAGACGAGGAGGAAGAGGATGATGAAGAAGAAATAGATGTTGTGACAGTGGAGAAAA GACGCTCCTCCTCCAACAAGGCTGTTACCACCCTCACTATTACAGTGCGTCCTAAAAATACCACTTTTCCATCGGTCAG GACACAGCAGAATGAACTGATTTTAAAGCGTTGTGCGCCAATTCACCAGCAGCATAATTATGCCGCTCCTTCTCCGTAT ATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTTAAAAGCCGAGGTGCCCCGTCCAGTAAAACCCATGATCCAACCAA AGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCGGAGGACAGCGAACGTCGACGTAACCATAATATCTTGGAGCGTCA GAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGTTAAGGGACCACGTTCCAGAACTTGTTAAAAATGAGAAAGCTGCA AAAGTTGTGATTTTGAAAAAAGCCACTGAATATGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTTATTGCTAGAAAAGG AGAAATTGCAAGCCAGGCAACAACAGTTGCTAAAGAAAATAGAGTACAAGCGGACTTGCTAA
Citation	Hu N, Strobl-Mazzulla P, Sauka-Spengler T, Bronner ME. DNA methyltransferase3A as a molecular switch mediating the neural tube-to-neural crest fate transition. Genes Dev. 2012 November 1; 26(21): 23802385.
Copyright	Copyright © 2012 by Cold Spring Harbor Laboratory Press
Comments	As insufficient information is provided in publication to verify exact sequence used to synthesize probe, the sequence below was obtained from NCBI NM_001031091

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-9

stage 9

Neural Crest
Neural Plate/Tube

Entry 3

GEISHA Id	MYCN.Anderson.2022	Data Source	Publication
Complete cDNA Template Probe	show CTCCGGGGACGACACGCTCAGACGACTCGGATGATGAAGACGAGGAGGAAGAGGATGATGAAGAAGAAATAGATGTTGT GACAGTGGAGAAAAGACGCTCCTCCTCCAACAAGGCTGTTACCACCCTCACTATTACAGTGCGTCCTAAAAATACCACT TTTCCATCGGTCAGGACACAGCAGAATGAACTGATTTTAAAGCGTTGTGCGCCAATTCACCAGCAGCATAATTATGCCG CTCCTTCTCCGTATATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTTAAAAGCCGAGGTGCCCCGTCCAGTAAAACC CATGATCCAACCAAAGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCGGAGGACAGCGAACGTCGACGTAACCATAAT ATCTTGGAGCGTCAGAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGTTAAGGGACCACGTTCCAGAACTTGTTAAAA ATGAGAAAGCTGCAAAAGTTGTGATTTTGAAAAAAGCCACTGAATATGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTT ATTGCTAGAAAAGGAGAAATTGCAAGCCAGGCAACAACAGTTGCTAAAGAAAATAGAGTACAAGCGGACTTGCTAAACT TCTTTTTCTCGTATATTATCATATATCTTGTTGGATATAAATATTTATATATTGGGTTGACCAGGACAGTCTTGTGCCA TTTGGCACATTTTGGGATTCCTTACAAAAAGAATTCGATATCACAGACTTATACAAAACCGGGACTCAAGGGGGGGCCC GTAACCA
Citation	Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Comments	Images and probe sequence provided by Claire Anderson. The probe was synthesized from cDNA clone ChEST442N13. Related paper: Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Dermomyotome
Ear/Otic Placode
Ectoderm
Endoderm
Forebrain
Hindbrain
Intermediate Mesoderm
Lateral Plate Mesoderm
Mesencephalon
Midbrain
Myelencephalon
Neural Crest
Neural Plate/Tube
Pharynx
Somatic Mesoderm
Somites
Splanchnic Mesoderm

Entry 4

GEISHA Id	MYCN.Anderson.2019	Data Source	Publication
Complete cDNA Template Probe	show CTCCGGGGACGACACGCTCAGACGACTCGGATGATGAAGACGAGGAGGAAGAGGATGATGAAGAAGAAATAGATGTTGT GACAGTGGAGAAAAGACGCTCCTCCTCCAACAAGGCTGTTACCACCCTCACTATTACAGTGCGTCCTAAAAATACCACT TTTCCATCGGTCAGGACACAGCAGAATGAACTGATTTTAAAGCGTTGTGCGCCAATTCACCAGCAGCATAATTATGCCG CTCCTTCTCCGTATATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTTAAAAGCCGAGGTGCCCCGTCCAGTAAAACC CATGATCCAACCAAAGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCGGAGGACAGCGAACGTCGACGTAACCATAAT ATCTTGGAGCGTCAGAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGTTAAGGGACCACGTTCCAGAACTTGTTAAAA ATGAGAAAGCTGCAAAAGTTGTGATTTTGAAAAAAGCCACTGAATATGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTT ATTGCTAGAAAAGGAGAAATTGCAAGCCAGGCAACAACAGTTGCTAAAGAAAATAGAGTACAAGCGGACTTGCTAAACT TCTTTTTCTCGTATATTATCATATATCTTGTTGGATATAAATATTTATATATTGGGTTGACCAGGACAGTCTTGTGCCA TTTGGCACATTTTGGGATTCCTTACAAAAAGAATTCGATATCACAGACTTATACAAAACCGGGACTCAAGGGGGGGCCC GTAACCA
Citation	Anderson C, Hill B, Lu HC, Moverley A, Yang Y, Oliveira NMM, Baldock RA, Stern CD. A 3D molecular atlas of the chick embryonic heart. Dev Biol. 2019 Dec 1;456(1):40-46. doi: 10.1016/j.ydbio.2019.07.003. Epub 2019 Jul 5.
Copyright	Copyright © 2019 Elsevier Inc. All rights reserved.
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Anderson et al. 2019.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

7-12

stage 12

Unlabeled

Entry 5

GEISHA Id	MYCN.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show CTCCGGGGACGACACGCTCAGACGACTCGGATGATGAAGACGAGGAGGAAGAGGATGATGAAGAAGAAATAGATGTTGT GACAGTGGAGAAAAGACGCTCCTCCTCCAACAAGGCTGTTACCACCCTCACTATTACAGTGCGTCCTAAAAATACCACT TTTCCATCGGTCAGGACACAGCAGAATGAACTGATTTTAAAGCGTTGTGCGCCAATTCACCAGCAGCATAATTATGCCG CTCCTTCTCCGTATATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTTAAAAGCCGAGGTGCCCCGTCCAGTAAAACC CATGATCCAACCAAAGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCGGAGGACAGCGAACGTCGACGTAACCATAAT ATCTTGGAGCGTCAGAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGTTAAGGGACCACGTTCCAGAACTTGTTAAAA ATGAGAAAGCTGCAAAAGTTGTGATTTTGAAAAAAGCCACTGAATATGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTT ATTGCTAGAAAAGGAGAAATTGCAAGCCAGGCAACAACAGTTGCTAAAGAAAATAGAGTACAAGCGGACTTGCTAAACT TCTTTTTCTCGTATATTATCATATATCTTGTTGGATATAAATATTTATATATTGGGTTGACCAGGACAGTCTTGTGCCA TTTGGCACATTTTGGGATTCCTTACAAAAAGAATTCGATATCACAGACTTATACAAAACCGGGACTCAAGGGGGGGCCC GTAACCA
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Trevers et al. 2023.

Stage

Image (click image to view full size)

Location (click to highlight)

Comments (click to highlight)

X-XIV

stage XIII

Area Pellucida
Epiblast

area pellucida epiblast except posteriorly

4-6

stage 4

stage 6

Epiblast
Neural Plate/Tube
Primitive Streak

anterior and lateral epiblast, lower near primitive streak
neural plate / primitive streak / neural plate border

7-9

stage 9

Hindbrain
Mesoderm
Neural Plate/Tube

neural plate / hindbrain mesenchyme / posterior mesoderm

all

Entry 6

GEISHA Id	MYC.Trevers.2023	Data Source	GEISHA ISH Analysis
Complete cDNA Template Probe	show GTCTTCCCCTTCCCCGTCAACAAGCGGGAGGCGGCGGTGCCAAGCGGCGGCGAGACCCCGCGGGGCGGCCGCCCGCCGC GTCCCGCGGGGGAGAGCCGGGCCAGCAGCAGCTCCGGGGACGACACGCTCAGCGACTCGGATGATGAAGACGAGGAGGA AGAGGATGATGAAGAAGAAATAGATGTTGTGACAGTGGAGAAAAGACGCTCCTCCTCCAACAAGGCTGTTACCACCCTC ACTATTACAGTGCGTCCTAAAAATACCACTTTTCCATCGGTCAGGACACAGCAGAATGAACTGATTTTAAAGCGTTGTG CGCCAATTCACCAGCAGCATAATTATGCCGCTCCTTCTCCATATATGGAGAGTGAAGATGTGCCACCACAGAAAAAGTT AAAAGCCGAGGTGCCCCGTCCAGTAAAACCCATGATCCAACCAAAGTCTAAGAGTTCAAGTCCTCGAAACTCTGATTCG GAGGACAGCGAACGTCGACGTAACCATAATATCTTGGAGCGTCAGAGGCGTAATGATCTGCGGTCCAGTTTCCTCACGT TAAGGGACCACGTTCCAGAACTTGTTAAACAATGAGGAAAGCTGCAAAAGCTGTGATTTTGAAAAAAGCCACTTGAATA TGTCCATTCCCTTCAGGCAGAGGAGCAGAAGTTATTGCTAGAAACAGGAGAAATTGCAAGCCAGGCAACAACAGTTGCT AACAGAACAATAGAGTACAG
Comments	The complete cDNA template sequence was obtained from the information from the publication as described in Trevers et al. 2023.